Postoperative surveillance of clinically nonfunctioning pituitary macroadenomas: markers of tumour quiescence and regrowth

Clinical Endocrinology
Y GreenmanN Stern

Abstract

Postoperative management of clinically nonfunctioning pituitary adenomas (NFPA) presents difficult challenges. There are no good serum markers for presence or growth of the tumour, medical treatment is not effective and radiotherapy carries the risk of significant side-effects. The purpose of this study was to investigate the natural history and biological behaviour of surgically treated NFPA, with a special effort to identify characteristics indicative of a more aggressive course that could assist in the clinical decision-making process. Patients operated on at our institution for NFPA undergo uniform routine clinical follow-up at the endocrine clinic. Magnetic resonance imaging (MRI) studies are performed 3, 6 and 12 months after transsphenoidal surgery and yearly thereafter for the first 5 years. Subsequently, imaging is performed once every 2 years or as clinically indicated. From 1992 onwards, no patient received immediate postoperative radiation therapy. One hundred and twenty-two patients (78M/45F) operated on at our institution since 1989 and with a minimal follow-up of 1 year comprised the study group. Tumour size and characteristics were determined by MRI using a modification of Hardy's and Wilson's classifications. M...Continue Reading

References

May 1, 1986·Journal of Neurosurgery·M J EbersoldR V Randall
Mar 1, 1974·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·G E Sheline
Apr 1, 1995·Baillière's Clinical Endocrinology and Metabolism·E R Laws, K Thapar
Oct 15, 1994·International Journal of Radiation Oncology, Biology, Physics·R W TsangW J Simpson
Mar 1, 1993·Endocrinology and Metabolism Clinics of North America·P J Snyder
May 1, 1993·The Journal of Clinical Endocrinology and Metabolism·L KatznelsonA Klibanski
May 14, 1998·Clinical Endocrinology·N J GittoesP M Stewart
Dec 2, 1998·Journal of Neurosurgery·P BreenA J Martinez
Sep 1, 1999·Clinical Endocrinology·P N Plowman
Jan 13, 2001·Clinical Endocrinology·A C WoollonsV Balakrishnan
Feb 9, 2002·European Journal of Endocrinology·Gustavo Soto-AresJean Pierre Pruvo

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Citations

Nov 4, 2006·Pituitary·Craig A Jaffe
Feb 21, 2008·Pituitary·Andrew A KannerYona Greenman
Aug 26, 2006·Nature Clinical Practice. Endocrinology & Metabolism·John S Bevan
May 2, 2008·Skull Base : Official Journal of North American Skull Base Society ... [et Al.]·Bruce MickeyEdward Ellis
May 2, 2012·Journal of Neurosurgery. Pediatrics·Mitsuo Yamaguchi-OkadaShozo Yamada
May 2, 2008·Neurosurgical Focus·Samer GhostineWalter D Johnson
Nov 30, 2006·European Journal of Endocrinology·Emanuele FerranteAndrea G Lania
Dec 24, 2005·Journal of Endocrinological Investigation·M J BarahonaS M Webb
Mar 3, 2007·Aging Clinical and Experimental Research·Patrizia Del MonteDonatella Bernasconi
Aug 6, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Jan Patrick BoströmKlaus Hamm
Dec 17, 2014·World Neurosurgery·Brandon A MillerNelson M Oyesiku
Sep 10, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·C KoppA-L Grosu
Oct 9, 2012·Neurosurgery Clinics of North America·Brandon A MillerNelson M Oyesiku
Mar 17, 2010·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Carmen Alameda HernandoCésar Varela Da Costa
Dec 1, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Yona Greenman, Naftali Stern
Nov 11, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sara C ErridgeAnna Gregor
Apr 12, 2008·International Journal of Radiation Oncology, Biology, Physics·Felicia E SneadWilliam M Mendenhall
Jan 30, 2008·Endocrinology and Metabolism Clinics of North America·Mark E Molitch
Feb 19, 2009·Clinical Endocrinology·Yona Greenman, Naftali Stern
Aug 19, 2007·Clinical Endocrinology·N KaravitakiJ A H Wass

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