PMID: 9179659Jan 1, 1997Paper

Postoperative UFT adjuvant and the risk factors for recurrence in renal cell carcinoma: a long-term follow-up study. Kyushu University Urological Oncology Group

International Journal of Urology : Official Journal of the Japanese Urological Association
S NaitoY Hiratsuka

Abstract

Radical nephrectomy is the standard therapy for low-stage renal cell carcinoma. However, recurrence sometimes develops even in patients who are considered to have undergone a curative resection of the primary tumor. The purpose of this study was to evaluate the usefulness of UFT (a 1:4 mixture of tegafur and uracil) adjuvant and the risk factors for recurrence in renal cell carcinoma. A prospective randomized trial was conducted to compare the use of long-term oral UFT adjuvant with nonadjuvant therapy after a radical nephrectomy for Robson stage I or II renal cell carcinoma. A multivariate analysis was also performed to estimate the risk factors for recurrence. A total of 71 patients were entered into this study, and 66 were evaluable (33 for each group). There was no significant difference in patient characteristics between the 2 groups. The nonrecurrence rate at 5 years after a radical nephrectomy was 80.5% and 77.1% in the UFT adjuvant group and the nonadjuvant group, respectively, with a median follow-up of 112.9 months; the difference was not significant. The toxicity of UFT was generally mild and tolerable. The tumor grade was found to be an important factor influencing recurrence. UFT cannot be universally recommended a...Continue Reading

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Citations

Jul 23, 2014·Clinical Genitourinary Cancer·Alvaro Pinto
Jun 18, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joseph I ClarkKim A Margolin
May 9, 2008·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Guilherme GodoySamir S Taneja
Jan 1, 2005·Current Opinion in Oncology·John W Eklund, Timothy M Kuzel
Apr 20, 2010·Asia-Pacific Journal of Clinical Oncology·Thean Hsiang TanDesmond Yip
Jun 28, 2014·The Oncologist·Sumanta K Pal, Naomi B Haas
Jun 22, 2012·Expert Review of Anticancer Therapy·Kiruthikah ThillaiSimon Chowdhury
Mar 28, 2019·Nature Reviews. Nephrology·Camillo PortaAxel Bex
Dec 11, 2020·OncoTargets and Therapy·Eliana M C TacconiAndrew Protheroe

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