Postovulatory cell death: why eggs die via apoptosis in biological species with external fertilization

The Journal of Reproduction and Development
Alexander A TokmakovVasily E Stefanov

Abstract

Spawned unfertilized eggs have been found to die by apoptosis in several species with external fertilization. However, there is no necessity for the externally laid eggs to degrade via this process, as apoptosis evolved as a mechanism to reduce the damaging effects of individual cell death on the whole organism. The recent observation of egg degradation in the genital tracts of some oviparous species provides a clue as to the physiological relevance of egg apoptosis in these animals. We hypothesize that egg apoptosis accompanies ovulation in species with external fertilization as a normal process to eliminate mature eggs retained in the genital tract after ovulation. Furthermore, apoptosis universally develops in ovulated eggs after spontaneous activation in the absence of fertilization. This paper provides an overview of egg apoptosis in several oviparous biological species, including frog, fish, sea urchin, and starfish.

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Citations

Jul 26, 2019·BioMed Research International·Alexander A TokmakovKen-Ichi Sato
Apr 11, 2020·Reproductive Medicine and Biology·Ken-Ichi Sato, Alexander A Tokmakov
Dec 29, 2020·Frontiers in Cell and Developmental Biology·Alexander A TokmakovKen-Ichi Sato

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Methods Mentioned

BETA
ubiquitination

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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