Postpartum NSAID Use and Adverse Outcomes among Women with Hypertensive Disorders of Pregnancy: A Systematic Review and Meta-analysis.

American Journal of Perinatology
Ashish PremkumarEmily S Miller

Abstract

This study was aimed to perform a systematic review and meta-analysis of the association between postpartum nonsteroidal anti-inflammatory drug (NSAID) use among women with hypertensive disorders of pregnancy (HDP) and risks of adverse postpartum outcomes. Studies were eligible if they included women who had been diagnosed with HDP and were postpartum, reported exposure to NSAIDs, were written in English, and were published between January 2000 and November 2019. Assessment of bias was performed using the Newcastle-Ottawa scale for observational studies or the Cochrane Collaborative tool for randomized trials. The primary outcome was maternal blood pressure ≥ 150 mm Hg systolic and/or 100 mm Hg diastolic. Secondary outcomes were persistent blood pressures ≥ 160 mm Hg systolic and/or 110 mm Hg diastolic, mean arterial pressure (MAP), initiation or up-titration of antihypertensive medication, length of hospital stay, rehospitalization for blood pressure control, and postpartum opioid use. A random-effect meta-analysis was performed using RevMan, with a p-value < 0.05 used to indicate statistical significance (PROSPERO CRD no.: 42019127043). Among 7,395 abstracts identified, seven studies (four randomized and three cohort studies,...Continue Reading

References

Nov 1, 1989·American Journal of Obstetrics and Gynecology·A SchoenfeldY Ovadia
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
May 18, 1999·American Journal of Obstetrics and Gynecology·M G ZlatnikR E Garfield
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Sep 23, 2003·Health Technology Assessment : HTA·J J DeeksUNKNOWN European Carotid Surgery Trial Collaborative Group
Feb 26, 2004·American Journal of Obstetrics and Gynecology·Angela MakrisAnnemarie Hennessy
Jun 21, 2008·BMJ : British Medical Journal·John P A IoannidisHannah R Rothstein
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Apr 15, 2014·Annals of Internal Medicine·John E CornellSteven N Goodman
Jun 25, 2015·Pregnancy Hypertension·Shane W WasdenDaniel W Skupski
Sep 8, 2015·Lancet·Ben W J MolG Justus Hofmeyr
Jul 8, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Paulino Vigil-De GraciaNelson Ortega
Dec 24, 2018·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Obstetrics
Feb 19, 2020·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·I BellosG Daskalakis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

Drug and Therapeutics Bulletin
Nursing RSA = Verpleging RSA
American Family Physician
D H Stern
The Journal of Rheumatology
L S Simon
© 2021 Meta ULC. All rights reserved