Postpolio syndrome and the late effects of poliomyelitis. Part 1. pathogenesis, biomechanical considerations, diagnosis, and investigations

Muscle & Nerve
Julian K Lo, Lawrence R Robinson

Abstract

Postpolio syndrome (PPS) is characterized by new muscle weakness and/or muscle fatigability that occurs many years after the initial poliomyelitis illness. Many theories exist regarding the pathogenesis of PPS, which remains incompletely understood. In contrast, the late effects of poliomyelitis are often a consequence of biomechanical alterations that occur as a result of polio-related surgeries, musculoskeletal deformities, or weakness. Osteoporosis and fractures of the polio-involved limbs are common. A comprehensive clinical evaluation with appropriate investigations is essential to fulfilling the established PPS diagnostic criteria. PPS is a diagnosis of exclusion in which a key clinical feature required for the diagnosis is new muscle weakness and/or muscle fatigability that is persistent for at least 1 year. Electromyographic and muscle biopsy findings including evidence of ongoing denervation cannot reliably distinguish between patients with or without PPS. Muscle Nerve 58:751-759, 2018.

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Citations

Oct 6, 2020·Physical & Occupational Therapy in Pediatrics·Julie M WernerMitchel Seruya
Jun 25, 2020·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Rutie Mamlok SherfRonit Koren
Jan 21, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Rutie Mamlok SherfRonit Koren
Jun 28, 2021·Physical Medicine and Rehabilitation Clinics of North America·Carol Vandenakker Albanese, Shailesh Reddy
Aug 12, 2021·São Paulo Medical Journal = Revista Paulista De Medicina·Claudio Andre Barbosa de LiraBeat Knechtle
Sep 11, 2021·Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·David GebauerAndreas Sandner-Kiesling

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