Postponing the Hypoglycemic Response to Partial Hepatectomy Delays Mouse Liver Regeneration

The American Journal of Pathology
Jiansheng HuangDavid A Rudnick

Abstract

All serious liver injuries alter metabolism and initiate hepatic regeneration. Recent studies using partial hepatectomy (PH) and other experimental models of liver regeneration implicate the metabolic response to hepatic insufficiency as an important source of signals that promote regeneration. Based on these considerations, the analyses reported here were undertaken to assess the impact of interrupting the hypoglycemic response to PH on liver regeneration in mice. A regimen of parenteral dextrose infusion that delays PH-induced hypoglycemia for 14 hours after surgery was identified, and the hepatic regenerative response to PH was compared between dextrose-treated and control mice. The results showed that regenerative recovery of the liver was postponed in dextrose-infused mice (versus vehicle control) by an interval of time comparable to the delay in onset of PH-induced hypoglycemia. The regulation of specific liver regeneration-promoting signals, including hepatic induction of cyclin D1 and S-phase kinase-associated protein 2 expression and suppression of peroxisome proliferator-activated receptor γ and p27 expression, was also disrupted by dextrose infusion. These data support the hypothesis that alterations in metabolism th...Continue Reading

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Citations

Dec 17, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Junyan TaoSatdarshan P Monga
Apr 25, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ekaterina KachayloBostjan Humar
Nov 20, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Estella M AlonsoEdward Doo
Jun 25, 2020·Hepatology International·Matias J CaldezPhilipp Kaldis
Mar 15, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna Alvarez-GuaitaCarles Rentero
Nov 19, 2018·The American Journal of Pathology·Stephen N GreenhalghNeil C Henderson
Jan 22, 2021·Gene Expression·Shikai Hu, Satdarshan P Monga
Jul 27, 2021·Trends in Endocrinology and Metabolism : TEM·Roya SolhiMassoud Vosough
Sep 13, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naroa Goikoetxea-UsandizagaMaría Luz Martínez-Chantar

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