Postprandial blood cell transcriptomics in response to the ingestion of dairy products by healthy individuals

The Journal of Nutritional Biochemistry
Francina M SagayaGuy Vergères

Abstract

The aim of this intervention study was to measure genome-wide postprandial gene expression in human blood cells after the ingestion of a single serving of milk, to identify the downstream physiological processes regulated by the differentially expressed genes, and to use this gene expression signature as a reference to compare it with the response following the ingestion of a transformed dairy product, namely, yogurt. We conducted a randomized, controlled, single-blinded, crossover study on six healthy male individuals. After an overnight fast, 540 g of milk or yogurt was ingested by the subjects. Blood samples were collected before (0 h) and after (2 h/4 h/6 h) ingestion, and the blood cell transcriptome was analyzed using a linear kinetic analysis that increases the statistical power of the study. The differentially expressed transcripts identified after the ingestion of milk (575 transcripts) and yogurt (625 transcripts) modulated similar biological processes. In particular, genes involved in protein biosynthesis and mitochondrial activities followed biphasic kinetics being down-regulated at 2 h and more pronouncedly up-regulated at 6 h. The opposite kinetics were observed for inflammatory and apoptotic processes during the ...Continue Reading

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Citations

Sep 23, 2014·Biological Trace Element Research·Hwayoung NohJayong Chung
Aug 3, 2013·Environmental and Molecular Mutagenesis·Cliona M McHaleMartyn T Smith
Nov 17, 2015·Current Nutrition Reports·Karina Standahl OlsenEiliv Lund
Feb 3, 2015·Molecular Nutrition & Food Research·Marine S Da Silva, Iwona Rudkowska
Nov 21, 2017·European Journal of Nutrition·Inês FigueiraCláudia N Santos
Sep 5, 2012·The British Journal of Nutrition·Guy VergèresMartin Gijs
Oct 28, 2021·The Journal of Experimental Biology·Aymam C de FigueiredoFernando R Gomes

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