PMID: 19149642Jan 20, 2009Paper

Postprandial glucose - a potential therapeutic target to reduce cardiovascular mortality

Current Vascular Pharmacology
Raj PeterDavid R Owens

Abstract

Cardiovascular disease (CVD) accounts for almost 75% of mortality in subjects with type 2 diabetes (T2DM). The relationship between hypertension, dyslipidaemia and CVD is now well established. However, the precise link between glycaemia and macrovascular complications has remained unclear. There is now emerging evidence that postprandial glucose (PPG) contributes significantly to CVD risk, although to date there are no large scale interventional studies underway which test the hypothesis that targeting PPG will reduce CVD risk. Until recently, there was no consensus about the definition of postprandial hyperglycaemia. The International Diabetes Federation (IDF) has now developed new clinical guidelines for postprandial glucose and recommend that 2-hour post meal glucose levels are kept <7.8 mmol/L. In the last few years more has become known about the cellular mechanisms triggered in response to glucose excursions which may explain this increased susceptibility to CVD. Recently, investigation into the contribution of PPG to HbA(1c) in subjects with T2DM, has shown that this is maximal in relatively well controlled diabetic subjects. Hence PPG is emerging as a legitimate therapeutic target to minimise CVD risk. This review addre...Continue Reading

Associated Clinical Trials

Citations

Oct 14, 2011·BMC Cardiovascular Disorders·Ruth MartíRafel Ramos
Jun 19, 2013·Indian Journal of Endocrinology and Metabolism·Tarunika BawaAmbrish Mithal
Nov 21, 2009·Diabetes Research and Clinical Practice·Hubert KolbRüdiger Landgraf
Nov 28, 2012·Primary Care Diabetes·Vito BorzìUNKNOWN IMPROVE™ Study Expert Panel
May 19, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Sarita BajajLeszek Czupryniak
Aug 7, 2010·Southern Medical Journal·Grant C Fowler, Deepa A Vasudevan
May 10, 2017·Diabetic Medicine : a Journal of the British Diabetic Association·S K Paul, R R Holman

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