Postprandial Hyperglycemia Stimulates Neuroglial Plasticity in Hypothalamic POMC Neurons after a Balanced Meal.

Cell Reports
Danaé NuzzaciAlexandre Benani

Abstract

Mechanistic studies in rodents evidenced synaptic remodeling in neuronal circuits that control food intake. However, the physiological relevance of this process is not well defined. Here, we show that the firing activity of anorexigenic POMC neurons located in the hypothalamus is increased after a standard meal. Postprandial hyperactivity of POMC neurons relies on synaptic plasticity that engages pre-synaptic mechanisms, which does not involve structural remodeling of synapses but retraction of glial coverage. These functional and morphological neuroglial changes are triggered by postprandial hyperglycemia. Chemogenetically induced glial retraction on POMC neurons is sufficient to increase POMC activity and modify meal patterns. These findings indicate that synaptic plasticity within the melanocortin system happens at the timescale of meals and likely contributes to short-term control of food intake. Interestingly, these effects are lost with a high-fat meal, suggesting that neuroglial plasticity of POMC neurons is involved in the satietogenic properties of foods.

Citations

Jul 4, 2020·Expert Review of Endocrinology & Metabolism·Ruth PrietoJosé M Pascual
Nov 27, 2020·Frontiers in Endocrinology·Jessica L HaighBeatrice M Filippi
Mar 17, 2021·Journal of Neuroendocrinology·Ismael González-GarcíaCristina García-Cáceres
Apr 6, 2021·Frontiers in Endocrinology·Olga Barca-Mayo, Miguel López
Jun 15, 2021·Frontiers in Endocrinology·Andrew FolickMartin Valdearcos
Jun 13, 2021·The Journal of Clinical Endocrinology and Metabolism·Alexandre Caron, Natalie Jane Michael
Jul 30, 2021·The Journal of Clinical Investigation·Tori LhommeVincent Prevot
Nov 6, 2021·Scientific Reports·P ÓrdenesMaría A García-Robles

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