Postprandial Hypertriglyceridemia Predicts Development of Insulin Resistance Glucose Intolerance and Type 2 Diabetes

PloS One
Mohammad AslamSri Venkata Madhu

Abstract

Insulin resistance (IR) and type 2 diabetes mellitus (T2DM) have been found to be associated with postprandial hypertriglyceridemia (PPHTg). However, whether PPHTg can cause IR and diabetes is not clear. We therefore investigated the role of PPHTg in development of T2DM in rat model of T2DM. 96 male Wistar rats were randomized into four groups (24 rats each). Control Group A, high sucrose diet (HSD) Group B, HSD+Pioglitazone (10 mg/kg/day) Group C and HSD+Atorvastatin (20 mg/kg/day) Group D. Fat and glucose tolerance tests were done at regular intervals in all groups besides insulin and body weight measurement. At 26 weeks, low dose streptozotocin (15 mg/kg, i.p.) was given to half of the rats. All rats were followed up till 48 weeks. PPHTg developed as early as week 2 in Group B and stabilized by week 14. Group B displayed highest PPHTg compared to other groups. Atorvastatin treatment (Group D) abolished PPHTg which became comparable to controls, pioglitazone treatment partially blunted PPHTg resulting in intermediate PPHTg. Group B with highest PPHTg showed highest subsequent IR, glucose intolerance (GI) and highest incidence of prediabetes at week 26 and diabetes at week 34 and 46 compared to other groups. Group D rats displ...Continue Reading

References

Nov 1, 1993·Diabetes Care·T Sane, M R Taskinen
May 1, 1997·The American Journal of Clinical Nutrition·W S Harris
Aug 21, 2001·Journal of Korean Medical Science·S ParkS K Lee
Jun 25, 2002·Diabetes Technology & Therapeutics·Allen B King, Dana U Armstrong
Aug 15, 2002·The Journal of Endocrinology·H Del ZottoJ J Gagliardino
Aug 23, 2002·European Journal of Pharmacology·Taro AokiYasushi Saito
May 29, 2004·The Journal of Biological Chemistry·Varman T SamuelGerald I Shulman
Aug 16, 2005·Diabetes Research and Clinical Practice·René KamgangJeanne Ngogang Yonkeu
Sep 3, 2008·Cell Metabolism·Alessandro DoriaC Ronald Kahn
Sep 18, 2008·American Journal of Physiology. Endocrinology and Metabolism·J CachoM P Ramos
Dec 22, 2009·Acta Pharmacologica Sinica·Ning ZhangZhu-fang Shen
May 6, 2015·Therapeutic Advances in Endocrinology and Metabolism·Nasser AghamohammadzadehHamidreza Ahadi

❮ Previous
Next ❯

Citations

Jun 18, 2017·International Journal of Molecular Sciences·Daisuke SatoHiroshi Maegawa
Jun 17, 2020·Experimental and Therapeutic Medicine·Yi MingHong-Yan Li
Sep 27, 2019·Advances in Nutrition·Kristin M HirahatakeSean H Adams
Nov 8, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·S GuptaS V Madhu
Jun 8, 2018·Journal of Agricultural and Food Chemistry·A Macho-GonzálezF J Sánchez-Muniz

❮ Previous
Next ❯

Methods Mentioned

BETA
light microscopy

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.