Postprandial hypotension is associated with more rapid gastric emptying in healthy older individuals

Journal of the American Medical Directors Association
Laurence G TrahairKaren L Jones

Abstract

Postprandial hypotension (PPH) occurs frequently in older individuals with disease and/or living in residential care, but its prevalence in "healthy" older individuals has not been evaluated in large cohorts. PPH is associated with substantial morbidity and increased mortality; current management is suboptimal. Recent studies suggest that the magnitude of the postprandial fall in blood pressure (BP) is related to the rate of gastric emptying (GE), so that relatively more rapid GE may potentially be a risk factor for PPH. We aimed to determine the prevalence of, and evaluate the association of GE with PPH. A total of 88 healthy "older", community-dwelling residents (47 women, 41 men; age 71.0 ± 0.5 years) attended a clinical research laboratory on a single occasion. Individuals consumed a 300 mL drink containing 75 g glucose and 150 mg C(13)-acetate. Exhaled breath was obtained for analysis of (13)CO2 and calculation of the 50% GE time (T50). BP and heart rate were assessed with an automated device. Eleven (12.8%) of 86 subjects had PPH (2 had diabetes and were excluded). GE was faster in subjects with PPH than the remainder of the group (T50 118.0 ± 9.4 vs 142.3 ± 4.6 minutes, P < .05). We conclude the prevalence of PPH in a co...Continue Reading

References

Oct 10, 2007·Clinics in Geriatric Medicine·Paul KuoMichael Horowitz
Mar 19, 2014·Journal of the American Medical Directors Association·Laurence G TrahairKaren L Jones

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Citations

Sep 4, 2016·Journal of the American Medical Directors Association·John E Morley
Jan 8, 2019·Diabetes, Obesity & Metabolism·Malcolm J BorgTongzhi Wu
Jan 29, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Hung PhamKaren L Jones
Jun 5, 2020·The Journal of Clinical Endocrinology and Metabolism·Xiang ZhangTongzhi Wu
Nov 13, 2015·Current Opinion in Clinical Nutrition and Metabolic Care·Stijn SoenenMichael Horowitz
Apr 15, 2019·Digestive Diseases and Sciences·Juan Gomez CifuentesScott Gabbard
May 28, 2020·Nature Reviews. Endocrinology·Emidio ScarpelliniJan Tack
Dec 11, 2020·Diabetes Research and Clinical Practice·Cong XieTongzhi Wu
Dec 4, 2020·Pharmaceuticals·Malcolm J BorgTongzhi Wu
Mar 7, 2021·Journal of the American Geriatrics Society·Caroline GiezenaarStijn Soenen
Aug 28, 2021·Nutrients·Malcolm J BorgTongzhi Wu

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