Postprandial improvement of gastric dysrhythmias in patients with type II diabetes: identification of responders and nonresponders

Digestive Diseases and Sciences
R MathurH C Lin

Abstract

Using the technique known as electrogastrography, we studied the postprandial response of gastric myoelectrial activity in subjects with type II diabetes. Seventy-one subjects with type II diabetes underwent 1 hr of fasting electrogastrography recording. HbA1c and fasting serum glucose levels were obtained. Subjects then underwent an additional 2 hr of electrogastrography recording in the post prandial state. Sixty of the 71 patients (85%) had gastric rhythm abnormalities in the fasting state. Forty-six of 71 subjects (65%) responded to the test meal by improving their electrogastrography tracings (responders) while 35% did not respond (nonresponders). The time spent in bradygastria during the fasting state by responders was 26.3+/-12.8% vs 10.9+/-8.5% for nonresponders (P < 0.0001). The percent tachygastria during the fasting state in responders was 19.8+/-13.0%, which was less than nonresponders (38.3+/-29.7%) (P < 0.001). Fasting plasma glucose and HbA1c could not be used to predict the gastric myoelectrical response to meal. In conclusion, gastric rhythm disturbances are common in type II diabetes; there was no correlation between HbA1c levels, age, duration of diabetes, or fasting serum glucose and gastric dysrhythmia in r...Continue Reading

Citations

Mar 25, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·X XuJ D Z Chen
Feb 8, 2002·World Journal of Gastroenterology : WJG·Hui-Bin QiXue-Qin Wang
Oct 21, 2004·The Journal of Pharmacology and Experimental Therapeutics·Radoslav ColeskiWilliam L Hasler
Apr 23, 2005·Digestive Diseases and Sciences·Gengqing SongJiande D Z Chen
Mar 10, 2009·Journal of Gastroenterology·Anna Kasicka-JonderkoZbigniew Gonciarz
Aug 1, 2006·Journal of Pediatric Gastroenterology and Nutrition·Ewa Toporowska-KowalskaJ Bodalski
Feb 4, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L A BradshawW O Richards

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