PMID: 8997213Dec 1, 1996Paper

Postprandial leg and splanchnic fatty acid metabolism in nonobese men and women

The American Journal of Physiology
T T NguyenM D Jensen

Abstract

These studies were conducted to determine whether there are gender-specific regional differences in meal triglyceride fatty acid uptake. Systemic and regional oleate ([3H]oleate) kinetics were measured in nine nonobese men and eight nonobese women before and at the end of a 6-h meal, administered as small frequent feedings to achieve steady-state chylomicronemia. Chylomicron uptake in the splanchnic bed accounted for 71 +/- 15% of meal triglyceride disappearance in men and 20 +/- 7% in women (P < 0.01), whereas leg chylomicron uptake could only account for 12 +/- 2 and 8 +/- 4% (P not significant in men vs. women) of meal triglyceride disappearance. Meal ingestion suppressed (P < 0.05) systemic and regional free fatty acid release in both men and women. Splanchnic nonchylomicron triglyceride release and leg nonchylomicron triglyceride uptake were not significantly different in men and women. In summary, the largest quantitative difference between men and women in fatty acid kinetics during meal ingestion is a substantially greater splanchnic uptake of meal triglyceride fatty acids in men. This could represent greater meal fatty acid storage in visceral adipose tissue.

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Citations

Nov 30, 2000·American Journal of Physiology. Endocrinology and Metabolism·Y ParkJ M Miles
May 9, 2003·American Journal of Physiology. Endocrinology and Metabolism·Michael D JensenAlan Cherrington
May 22, 2008·American Journal of Physiology. Endocrinology and Metabolism·Sylvia Santosa, Michael D Jensen
Jan 11, 2013·Physiological Reviews·André Tchernof, Jean-Pierre Després
Nov 9, 2002·American Journal of Physiology. Endocrinology and Metabolism·Tracy J HortonDaniel H Bessesen
Jul 27, 2000·American Journal of Physiology. Endocrinology and Metabolism·S A RomanskiM D Jensen
Feb 8, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Jacques Delarue, Christophe Magnan
Aug 15, 2013·American Journal of Physiology. Endocrinology and Metabolism·ZengKui Guo, Michael D Jensen
Jun 15, 2016·Journal of Exercise Nutrition & Biochemistry·Aaron ChuStephen H Boutcher
Jul 27, 2000·American Journal of Physiology. Endocrinology and Metabolism·S A RomanskiM D Jensen
Jun 29, 2006·American Journal of Physiology. Endocrinology and Metabolism·Matthew R JackmanDaniel H Bessesen
Aug 5, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Faidon Magkos, Labros S Sidossis
May 18, 2007·Annual Review of Nutrition·Susanne B Votruba, Michael D Jensen
Nov 17, 2020·American Journal of Physiology. Endocrinology and Metabolism·Lili ZhangMichael D Jensen
Jan 26, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Sanjay KalraGanapathi Bantwal
Aug 1, 2007·Diabetes·Susanne B VotrubaMichael D Jensen

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