Postprandial lipaemia, metabolic syndrome and LDL particle size in urbanised South African blacks with and without coronary artery disease

QJM : Monthly Journal of the Association of Physicians
L M NtyintyaneG V Gill

Abstract

Postprandial lipaemia, characterised by a rise in triglycerides (TG) after eating, is associated with coronary artery disease (CAD) and metabolic syndrome (MetS). Small, dense, low-density lipoprotein (LDL) particles are implicated in atherogenesis. Little is known about postprandial lipaemia or small, dense LDL particles in urbanised black South Africans. Assess postprandial lipaemia in black CAD patients with and without MetS and measure their fasting and postprandial lipid profiles and LDL particles. Anthropometric data, biochemical variables and LDL particles were measured in 40 patients and 20 control subjects. Twenty three patients met International Diabetes Federation criteria for MetS and were subdivided according to fasting TG concentration either < or > or = 1.7 mmol/l. Postprandial lipaemia was assessed by an oral fat tolerance test (OFTT) and area under the curve (AUC). CAD patients with and without MetS had similar fasting lipid profiles, postprandial responses during OFTT and AUCs. MetS patients with fasting TG > or = 1.7 mmol/l had greater postprandial responses (P < 0.001) and higher AUC (P < 0.0001) than patients with TG < 1.7 mmol/l. AUC was higher in all patients than controls (P < 0.03). The most significant...Continue Reading

Citations

Apr 29, 2010·Current Diabetes Reports·Kwame Osei
Nov 26, 2008·Metabolic Syndrome and Related Disorders·Lucas NtyintyaneGeoffrey Gill
Nov 3, 2011·American Journal of Physiology. Endocrinology and Metabolism·Ranganath MuniyappaAnne E Sumner
Sep 3, 2010·Journal of Atherosclerosis and Thrombosis·Dal-Sik KimSeul-Ki Jeong
Apr 26, 2011·Clinical and Experimental Hypertension : CHE·Leandi LammertynLeoné Malan

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