Postprandial lipaemia suppresses endothelium-dependent arterial dilation in patients with hypothyroidism.

Endocrine
Guang Da XiangLin Shuang Zhao

Abstract

Endothelial dysfunction represents an early step in the development of atherosclerosis. The purpose of this study was to investigate the relationship between postprandial lipaemia and endothelial dysfunction in patients with overt hypothyroidism (oHT) and subclinical hypothyroidism (sHT). Female subjects with oHT and sHT, as well as female healthy subjects with euthyroid state were enrolled (10 cases in each group). The examination of flow-mediated dilation (FMD) was performed before and after an oral fat-loading by high resolution ultrasound. Endothelial dysfunction after an oral fat challenge was related to the extent of hypertriglyceridemia and free radicals. FMD decreased significantly at 4-h point in 3 groups, (p < 0.05) and then FMD in control and sHT restored to baseline at 8-h point, it was lower than baseline in sHT group at 6-h point (p = 0.042). However, FMD continued to decrease at 6-h point (p < 0.001), and then increased toward to baseline at 8-h point, which was still lower than baseline (p = 0.039) in oHT. Spearman's analysis showed a negative correlation between FMD and triglyceride, a negative correlation between FMD and thiobarbituric acid reactive substances (TBARS), and a positive correlation between trigly...Continue Reading

References

Sep 1, 1979·Circulation·D B Zilversmit
Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
Nov 11, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J R PatschW Patsch
Nov 1, 1996·The American Journal of Physiology·J S Beckman, W H Koppenol
Feb 1, 1997·The American Journal of Cardiology·R A VogelG D Plotnick
Jul 10, 1999·Journal of the American College of Cardiology·H KawanoH Yasue
Dec 3, 1999·Journal of Internal Medicine·F Karpe
Nov 18, 2000·Journal of the American College of Cardiology·R A VogelG D Plotnick
Feb 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Piero O BonettiAmir Lerman
Jul 14, 2004·Endocrine·Bernadette Biondi, Irwin Klein
Aug 28, 2004·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·G B VignaR Fellin
Oct 13, 2004·Seminars in Vascular Medicine·Stephen Nicholls, Pia Lundman
Jul 28, 2005·The Journal of Clinical Endocrinology and Metabolism·Xiang Guang-daZhao Lin-shuang
Feb 18, 2006·Journal of Endocrinological Investigation·X Guang-DaZ Lin-Shuang
Apr 16, 2009·Endocrine·Cihangir Erem
Feb 18, 2010·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Xiang G DZhao L S

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Citations

Jan 24, 2014·Endocrine·Limin TianLuyan Zhang
Sep 25, 2012·Heart Failure Clinics·Jeong-a KimMichael J Quon
Jan 24, 2016·Thyroid : Official Journal of the American Thyroid Association·Anne Nm McGowanJames Gibney
Dec 3, 2014·Experimental and Therapeutic Medicine·Ming LuJia-Jun Zhao
May 6, 2014·Progress in Lipid Research·Bill Lands
Jul 15, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Bill Lands

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