PMID: 2102083Dec 1, 1990Paper

Postprandial lipemia, fenofibrate and coronary artery disease

Atherosclerosis
H S SimpsonJ Shepherd

Abstract

This report describes the response of patients with severe coronary artery disease to a dynamic fat load test and monitors the change induced by fenofibrate therapy. The presence of disease was associated with prolonged and exaggerated hypertriglyceridemia following the meal and with lower basal HDL cholesterol and HDL subfraction masses. A further indicator of risk was the persistence of increased amounts of retinyl palmitate in the plasma of severely affected individuals 24 h after its ingestion with the meal. These observations are consistent with the proposal that the clearance of chylomicrons and their remnants is impaired in coronary atherosclerosis. Fenofibrate reduced alimentary lipemia following the fat load in both normo- and hypercholesterolemic subjects. This was associated with a 10% rise in plasma HDL cholesterol levels. The improvement in chylomicron catabolism probably derived from a 37% increase (P less than 0.001) in lipoprotein lipase activity induced by fenofibrate. Hepatic lipase on the other had was only slightly affected by treatment.

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Citations

Mar 1, 1993·Medicinal Research Reviews·G Franceschini, R Paoletti
Jan 1, 1996·European Journal of Applied Physiology and Occupational Physiology·N V Tsetsonis, A E Hardman
May 29, 2008·European Journal of Nutrition·Niels Peter MöllerJürgen Schrezenmeir
Dec 21, 2000·Current Atherosclerosis Reports·W PatschJ R Patsch
Mar 1, 1994·Atherosclerosis·F KarpeA Hamsten
Aug 1, 1994·Atherosclerosis·A GawJ Shepherd
Jul 1, 1996·Atherosclerosis·J Davignon, J S Cohn
Jan 15, 1996·Thrombosis Research·N XuA Nilsson
Jun 16, 2005·Diabetes Research and Clinical Practice·Jamal AhmadIbne Ahmad
Feb 1, 1997·The American Journal of Cardiology·R A VogelG D Plotnick
Aug 21, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Katia A AlmeidaRaul C Maranhão
Mar 20, 2001·Atherosclerosis·R BissonnetteJ Genest
Oct 28, 1998·Progress in Cardiovascular Diseases·L M Belalcazar, C M Ballantyne
Oct 17, 1998·Pharmacology & Therapeutics·D Bhatnagar
Feb 21, 2004·International Journal of Cardiology·Ana Paula M ChacraRaul C Maranhão

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