PMID: 8604667Jan 1, 1996Paper

Postprandial lipemia: the origin of an early peak studied by specific dietary fatty acid intake during sequential meals

The American Journal of Clinical Nutrition
B A FieldingK N Frayn

Abstract

Previous studies have noted the presence of an early postprandial peak in plasma triacylglycerol concentration, particularly when successive meals have been consumed. We tested the hypothesis that fat from a previous meal contributes to this early postprandial lipemia. We investigated the effect of consuming a lunch containing 61 g fat 5 h after a breakfast containing 54 g fat. The predominant fatty acids in the first meal, expressed as % by wt of total fatty acids, were 18:2 (linoleic acid), 68%, and 18:1 (oleic acid), 19%. The main fatty acids in the second meal were 18:1 (75%) and 18:2 (8%). After lunch, the early peak (at 50-60 min) in chylomicron triacylglycerol was found to contain a large proportion of 18:2, the main constituent of the first meal, whereas at later time points the chylomicron triacylglycerol fatty acid profile more closely resembled that of the second meal. Control studies in three subjects showed the complete absence of the early peaks in plasma and chylomicron triacylglycerol concentrations when either the lunch was omitted or the first meal was low in fat. The plasma nonesterified fatty acid profile also showed a corresponding peak in 18:2 at 50-60 min, which may represent the release into the plasma o...Continue Reading

Citations

Jul 1, 1997·The British Journal of Nutrition·H A WhitleyK N Frayn
Dec 3, 1999·Journal of Internal Medicine·F Karpe
Feb 27, 2001·Current Opinion in Clinical Nutrition and Metabolic Care·B A Griffin, B A Fielding
Jun 26, 2002·The American Journal of Clinical Nutrition·M Denise RobertsonKeith N Frayn
Jun 5, 2003·Journal of Lipid Research·Shawna L LemkeAndrew J Clifford
Sep 18, 2003·The British Journal of Nutrition·Ruth D SmithChristine M Williams
Dec 4, 2003·European Journal of Clinical Nutrition·G C BurdgeS A Wootton
Jan 30, 2008·European Journal of Nutrition·Carmen Herrero-BarbudoBegoña Olmedilla-Alonso
Oct 23, 2008·American Journal of Physiology. Endocrinology and Metabolism·Leanne HodsonBarbara A Fielding
Dec 17, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Richard D Mattes
Jan 1, 2009·Metabolomics : Official Journal of the Metabolomic Society·Angela M ZivkovicJ Bruce German
Aug 6, 2020·Frontiers in Microbiology·Pooja AgarwalFernando O Martinez
Jul 1, 1997·The Proceedings of the Nutrition Society·K N FraynB A Fielding
Oct 30, 2001·The Proceedings of the Nutrition Society·C M KellyC M Williams
Mar 29, 2003·The American Journal of Clinical Nutrition·Thomas A B SandersGeorge J Miller
Jun 19, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Matthias OrthClaus Luley
Dec 21, 2002·The British Journal of Nutrition·M D RobertsonK N Frayn
Sep 30, 2006·European Journal of Nutrition·Carmen Herrero-BarbudoInmaculada Blanco-Navarro
Jun 23, 2009·The British Journal of Nutrition·Kerry S JonesW Andy Coward
Mar 31, 2006·The British Journal of Nutrition·Astrid J P G Smeets, Margriet S Westerterp-Plantenga
Aug 21, 2008·The Journal of Clinical Endocrinology and Metabolism·Garry D TanFredrik Karpe
Apr 26, 2007·European Journal of Clinical Nutrition·D LaironC Williams
Jun 29, 2006·American Journal of Physiology. Endocrinology and Metabolism·Susanne B Votruba, Michael D Jensen
Mar 19, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Nicolas D KnuthJeffrey F Horowitz
Sep 29, 2011·Diabetes·Fredrik KarpeKeith N Frayn
Aug 9, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J TentorE C de Faria
Jun 8, 2017·European Journal of Clinical Nutrition·M E Clegg
Jul 31, 1998·The British Journal of Nutrition·K EvansK N Frayn

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