Postprandial metabolic responses to ingestion of bovine glycomacropeptide compared to a whey protein isolate in prediabetic volunteers

European Journal of Nutrition
Anja S HoefleHannelore Daniel

Abstract

Whey protein was shown to reduce blood glucose responses in humans and various other positive effects have been attributed to this protein. In contrast, studies using glycomacropeptide (GMP) as part of the whey fraction of bovine milk are rare. We, therefore, studied the postprandial responses to GMP administration in humans with impaired glucose tolerance compared to the effects of pure whey protein in a random design. Fifteen prediabetic volunteers received on different occasions one of three test drinks containing 50 g of maltodextrin19 (MD19) alone or in combination with either 50 g GMP or 50 g whey protein isolate (WPI). Blood was collected over 4 h with analysis of blood glucose and hormones, gastric emptying rate as well as plasma amino- and fatty acids, β-hydroxybutyrate and acylcarnitines. The WPI drink reduced the AUC of venous blood glucose compared to the MD19 drink in the prediabetic group by 11% (p = 0.0018) whereas GMP reduced the AUC by 18% (p < 0.0001), significantly different to the WPI drink (p = 0.0384). The reduction in blood glucose after the GMP drink was accompanied by a significantly lower AUC of insulin (- 34%) than for the WPI drink. Levels of C-peptide and of glucose insulinotropic polypeptide (GIP) ...Continue Reading

References

Jan 1, 1990·Neuroscience and Biobehavioral Reviews·N Geary
Oct 9, 1969·The New England Journal of Medicine·P FeligG F Cahill
Sep 1, 1980·The American Journal of Clinical Nutrition·M AhmedR F Lamusga
May 1, 1982·The Journal of Surgical Research·N N AbumradW W Lacy
Jan 1, 1994·Reproduction, Nutrition, Development·M YvonT Corring
Aug 14, 2001·American Journal of Physiology. Endocrinology and Metabolism·J S GreiweC F Semenkovich
Oct 20, 2001·European Journal of Clinical Nutrition·H Liljeberg Elmståhl, I Björck
Dec 4, 2003·Biochemical and Biophysical Research Communications·Masako DoiMitsuo Nakayama
Feb 17, 2006·European Journal of Clinical Nutrition·M von Post-SkagegårdB Karlström
Nov 17, 2006·Diabetes/metabolism Research and Reviews·Paolo TessariClara Garcia-Rodenas
Dec 8, 2007·The British Journal of Nutrition·Peter J RoylePeter M Clifton
Nov 18, 2008·Metabolism: Clinical and Experimental·Dionysia KalogeropoulouFrank Q Nuttall
Dec 11, 2008·American Journal of Physiology. Endocrinology and Metabolism·Xinjie ZhaoRainer Lehmann
Feb 27, 2009·The American Journal of Clinical Nutrition·Sandra C van CalcarDenise M Ney
Nov 20, 2009·The American Journal of Clinical Nutrition·Xiaomiao Lan-Pidhainy, Thomas M S Wolever
Mar 9, 2010·The British Journal of Nutrition·Jennifer B KeoghPeter M Clifton
Mar 8, 2013·The American Journal of Clinical Nutrition·Anita BelzaArne Astrup

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Citations

Apr 28, 2020·Antioxidants & Redox Signaling·Mathilde Foisy SauvéEmile Levy

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