Postprandial paradoxical IGFBP-1 response in obese patients with Type 2 diabetes

Clinical Science
Mikael LehtihetK Brismar

Abstract

IGFs (insulin-like growth factors), which in an unbound form induce glucose and amino acid uptake, circulate bound to IGFBPs (IGF-binding proteins), which modulate their bioavailability and activity. The aim of the present study was to examine the effect of a standard meal [2301 kJ (550 kcal)] on the serum levels of IGFBP-1 in obese patients with T2DM (Type 2 diabetes mellitus), non-obese patients with T1DM (Type 1 diabetes mellitus) and healthy controls, using the artificial pancreas (Biostator) to obtain a normal glycaemic response to the meal. IGFBP-1 levels decreased by 50% over 2 h following the meal at a similar clearance in both the healthy controls and patients with T1DM, but no significant decline was seen in the patients with T2DM, despite a several-fold increase in insulin levels. The patients with T2DM were also studied during Sandostatin (somatostatin) infusion to decrease the inappropriate secretion of glucagon during the meal. During the 210 min of somatostatin infusion, the glucagon response was suppressed and IGFBP-1 levels were increased concomitantly with the peak in insulin levels, without any significant decrease after the meal. In conclusion, the impaired IGFBP-1 response to meal-related hyperinsulinaemia ...Continue Reading

References

Jul 1, 1990·Physiological Reviews·V R Sara, K Hall
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J I JonesD R Clemmons
Aug 1, 1991·Molecular and Cellular Endocrinology·M S Lewitt, R C Baxter
Jan 1, 1986·Advances in Clinical Chemistry·R C Baxter
Sep 1, 1987·The Journal of Clinical Endocrinology and Metabolism·R C Baxter, C T Cowell
Jan 1, 1989·The Journal of Clinical Endocrinology and Metabolism·A M SuikkariH Yki-Järvinen
Sep 1, 1988·Journal of Endocrinological Investigation·K BrismarK Hall
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher
Nov 1, 1982·Forensic Science International : Synergy·M OshimaM Hara
Oct 1, 1995·Metabolism: Clinical and Experimental·J FrystykH Orskov
Feb 1, 1994·Diabetes Research and Clinical Practice·M S Lewitt
Oct 1, 1996·Baillière's Clinical Endocrinology and Metabolism·A M Umpleby, D L Russell-Jones
Oct 16, 1999·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·K S Polonsky
May 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·R C Baxter
Feb 13, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·I ZachrissonP Bang
Apr 27, 2002·The American Journal of Clinical Nutrition·Mark A PereiraElizabeth R Seaquist
May 11, 2002·Scandinavian Journal of Clinical and Laboratory Investigation·L H OttesenA Flyvbjerg
Jul 20, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Agneta HildingKerstin E Hall
Sep 1, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Steven A Rosenzweig
Sep 1, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jan Frystyk
Mar 1, 2005·Metabolism: Clinical and Experimental·Moira S LewittKerstin Brismar
May 17, 2005·Current Molecular Medicine·B Ahrén
Jul 2, 2005·Current Opinion in Lipidology·Giulio MarchesiniElisabetta Bugianesi
Jun 17, 2006·Minerva cardioangiologica·G Marchesini, M Babini

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Citations

Jul 27, 2017·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Daniel Wolverton, Melissa M Blair
Dec 23, 2014·The Journal of Clinical Endocrinology and Metabolism·Jesper S SorensenUNKNOWN Danish Society for Diabetes in Childhood and Adolescence

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