Postprandial triglyceride response in normolipidemic, hyperlipidemic and obese subjects - the influence of polydextrose, a non-digestible carbohydrate

Nutrition Journal
Kirsti TiihonenTommi Vasankari

Abstract

Three independent trials were conducted to evaluate postprandial triglyceride (TG) responses in subjects with different lipid metabolism. The effect of polydextrose (PDX), a soluble non-digestible carbohydrate, on postprandial response was also studied using practically relevant, high fat meal interventions. A total of 19 normolipidemic (average BMI 24.1 kg/m(2)), 21 overweight/hyperlipidemic (average BMI 29.6 kg/m(2)) and 18 obese/non-diabetic subjects (average BMI 33.6 kg/m(2)) were included in the study. On two separate occasions all subjects ate two high-fat meals (4293 kJ, 36% from fat), one with PDX (either 12.5 g or 15 g) and one without PDX during placebo-controlled, double-blind, crossover and randomized trials. To obtain the triglyceride measurements venous blood samples were taken before the consumption of the test meal and five times afterwards, up to 6 h post-test meal. The triglyceride responses were modeled using a mixed-effects linear model. The key variables that explain the variation of the postprandial triglyceride response in the different subject groups were: baseline triglyceride concentration, time point, and PDX vs. placebo treatment (p < 0.05). The maximum postprandial TG concentration was more pronounc...Continue Reading

References

Jan 1, 1992·The American Journal of Clinical Nutrition·L CaraD Lairon
Nov 11, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J R PatschW Patsch
Aug 1, 1992·The Journal of Clinical Endocrinology and Metabolism·N M O'MearaK S Polonsky
Oct 1, 1990·The Journal of Clinical Endocrinology and Metabolism·G F LewisK S Polonsky
Feb 1, 1983·The American Journal of Clinical Nutrition·M L KashyapR L Jackson
May 30, 1998·Diabetes·C CouillardJ P Després
Jan 30, 1999·The American Journal of Clinical Nutrition·L BrownF M Sacks
Nov 13, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·A P van BeekT W de Bruin
Apr 11, 2001·Journal of the American College of Nutrition·P M SuterE Hänseler
Apr 26, 2001·The British Journal of Nutrition·O Murphy
Jan 5, 2002·Journal of Nutritional Science and Vitaminology·K HigashiH Nakamura
Jan 10, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C J HalkesD W Erkelens
Apr 30, 2002·European Heart Journal·H-M LakkaJ T Salonen
Dec 3, 2003·Atherosclerosis·Patricia BlackburnJean Pierre Després
Jul 6, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M T FloodS A S Craig
Nov 3, 2006·The Journal of Nutritional Biochemistry·Denis LaironDominique Jourdheuil-Rahmani
Nov 10, 2006·Critical Reviews in Food Science and Nutrition·Cheryl L Dikeman, George C Fahey
Mar 30, 2007·The British Journal of Nutrition·Francesca FavaNina Rautonen
Jul 10, 2007·The Journal of Nutritional Biochemistry·Milagros GalisteoAntonio Zarzuelo
Jul 20, 2007·JAMA : the Journal of the American Medical Association·Børge G NordestgaardAnne Tybjaerg-Hansen
Jul 20, 2007·JAMA : the Journal of the American Medical Association·Sandeep BansalPaul M Ridker
Aug 21, 2007·The British Journal of Nutrition·José Lopez-MirandaDenis Lairon
Feb 2, 2008·Nutrition Reviews·Michael H AuerbachKenneth C Hayes
Aug 9, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jouko SundvallGeorg Alfthan
Sep 5, 2009·Journal of Atherosclerosis and Thrombosis·Rie OkaMasakazu Yamagishi
May 12, 2010·International Journal of Clinical Practice·J P WallaceK Mather
Aug 20, 2010·Annals of Medicine·Markku AhotupaTommi Vasankari
Feb 15, 2011·Current Vascular Pharmacology·Genovefa D KolovouGeorge Panotopoulos
Oct 1, 2011·International Journal of Vascular Medicine·Boudewijn KlopManuel Castro Cabezas
Apr 16, 2013·Nutrients·Boudewijn KlopManuel Castro Cabezas
Sep 19, 2014·European Journal of Clinical Investigation·Pablo Perez-MartinezJose Lopez-Miranda

❮ Previous
Next ❯

Citations

Oct 30, 2016·Journal of Functional Foods·Alan MackieBalazs Bajka
Oct 26, 2016·Journal of Lipid Research·Chao-Qiang LaiJosé M Ordovás
Oct 6, 2018·Molecular Nutrition & Food Research·Kaisa AiraksinenKirsti Tiihonen
Mar 21, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Engy ShokryOlaf Uhl
Jan 7, 2020·The British Journal of Nutrition·Xinjie LinAmanda J Wright
Jul 21, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Grace AustinManohar L Garg

❮ Previous
Next ❯

Software Mentioned

R
R Core Team ,
R Foundation for Statistical Computing
nlme library

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.