Postradiation Histiocytic Sarcoma in the Setting of Muir-Torre Syndrome

Case Reports in Pathology
Erin BaumgartnerDeniz Peker

Abstract

Hereditary nonpolyposis colorectal carcinoma (HNPCC) is an autosomal dominant genetic disorder characterized by a predisposition towards colorectal carcinoma and other extracolonic neoplasms. Histiocytic sarcoma (HS) is a very rare hematologic neoplasm characterized by a malignant proliferation of cells with histiocytic differentiation. We present the case of a 62-year-old male with previous diagnosis of MTS who presented with metastatic colorectal adenocarcinoma, bilateral papillary renal cell carcinoma, and a new squamous cell carcinoma of the scalp, treated with resection and adjuvant radiation therapy. After reconstructive surgery for his scalp resection, the patient developed a persistent nonhealing skin defect. A punch biopsy of this nonhealing skin defect and subsequent immunohistochemistry revealed neoplastic histiocytic cells restricted to the epidermis and underlying dermis. The diagnosis of cutaneous histiocytic sarcoma was then rendered. Histiocytic sarcoma is an exceptionally rare malignancy. Consequently, there is no universally agreed upon management protocol for this malignancy. The patient was admitted to hospice and treated with palliative radiation. This case demonstrates the need for awareness of the risk of...Continue Reading

References

Mar 7, 2003·The New England Journal of Medicine·Henry T Lynch, Albert de la Chapelle
Aug 12, 2008·Seminars in Oncology·Lucy A Godley, Richard A Larson
Dec 24, 2009·Hereditary Cancer in Clinical Practice·Dewkoemar RamsoekhErnst J Kuipers
Jan 10, 2013·Virchows Archiv : an International Journal of Pathology·Masato YozuKp Wong
Jun 27, 2013·Journal of Clinical and Experimental Hematopathology : JCEH·Emiko Takahashi, Shigeo Nakamura
Nov 1, 2013·Anais Brasileiros De Dermatologia·Flávia TrevisanMarcella Ledo Martins
Mar 23, 2017·The American Journal of Dermatopathology·Meera Mahalingam
May 16, 2017·The Surgical Clinics of North America·Katerina Wells, Paul E Wise

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