PMID: 1201124Nov 1, 1975Paper

Postsecretory reabsorption of urate in man

Arthritis and Rheumatism
H S Diamond, A D Meisel

Abstract

These results are consistent with a model for renal tubular transport of urate in which there is reabsorption of both filtered and secreted urate. Urate secretion greatly exceeds total urate excretion, and most secreted urate is reabsorbed. At least a portion of urate reabsorption occurs at a site distal to or coextensive with the urate secretory site. There appear to be at least two distinct reabsorptive mechanisms for urate. The results of the flow rate and vasopressin studies are consistent with the hypothesis that urate reabsorption occurs in both the distal and the proximal tubule in man. The distal reabsorptive site appears to be quite small. It may be passive since it does not appear to be inhibited by uricosuric drugs. This reabsorptive site may account for less than 15% of total urate reabsorption. Both volume expansion and probenecid may inhibit urate absorption only in the proximal tubule. Thus reabsorption in the proximal tubule coud account for more than 90% of total urate reabsorption. Reabsorption at the postulated collecting duct reabsorptive site appears to be too small in magnitude to account for all reabsorptions of secreted urate. This could be explained if the reabsorptive site in the proximal tubule is coe...Continue Reading

References

Apr 9, 1975·Pflügers Archiv : European journal of physiology·H Diamond, A Meisel
Jun 1, 1973·The Journal of Clinical Investigation·H S Diamond, J S Paolino
Jul 1, 1972·Arthritis and Rheumatism·H S DiamondD Halberstam
Jan 1, 1968·The American Journal of Physiology·W B BlytheL G Welt
Jul 1, 1968·The Journal of Clinical Investigation·S S HowardsR W Berliner
Oct 1, 1957·Proceedings of the Society for Experimental Biology and Medicine·B W AGRANOFFJ AXELROD
Oct 1, 1959·The Journal of Clinical Investigation·A B GUTMANL BERGER
Jul 1, 1965·The Journal of Clinical Investigation·J H DIRKSR W BERLINER
Apr 1, 1950·The Journal of Clinical Investigation·R W BERLINERT J KENNEDY

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Citations

Jan 1, 1977·American Journal of Hematology·S P BallouJ W Harris
Jun 25, 2016·Clinical and Experimental Nephrology·Takanori KumagaiShunya Uchida
Jan 1, 1977·British Journal of Obstetrics and Gynaecology·W Dunlop, J M Davison
Jun 1, 1978·The Journal of Pediatrics·F B StapletonA B Gruskin
Aug 1, 1980·Kidney International·J M Davison, W Dunlop

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