Poststroke neurological improvement within 7 days is associated with subsequent deterioration

Stroke; a Journal of Cerebral Circulation
Stella AslanyanGAIN International Steering Committee and Investigators

Abstract

Improvement in the National Institutes of Health Stroke Scale (NIHSS) 24 hours after stroke has been associated with subsequent neurological deterioration. We hypothesized that a similar association would be apparent for events occurring after 7 days, when acute changes from edema and herniation are less common. We evaluated the degree of NIHSS improvement at 7 days (recovery) as a predictor of subsequent neurological deterioration from day 7 to day 90. We studied all patients of the Glycine Antagonist (gavestinel) In Neuroprotection (GAIN) International Trial with ischemic stroke alive at day 7, excluding patients with hemorrhagic events and deaths from nonstroke-related causes. The GAIN International Trial was a randomized, double-blind, placebo-controlled, and parallel-group trial; because the study drug had no effect on stroke outcome, treatment groups were combined for this analysis. Neurological deterioration was assessed by the combined measure, including: (1) stroke-related events recorded as "serious adverse events," (2) recurrent stroke recorded on a separate case report form, and (3) any NIHSS worsening. Among 1187 patients included, 25% had >65% recovery. Deterioration was more prevalent in the group with >65% early...Continue Reading

References

Dec 14, 1995·The New England Journal of Medicine·UNKNOWN National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
Dec 14, 1995·The New England Journal of Medicine·R KayA Wong
Jan 9, 2001·JAMA : the Journal of the American Medical Association·S C JohnstonS Sidney
Sep 6, 2003·Stroke; a Journal of Cerebral Circulation·S Claiborne Johnston, J Donald Easton
Oct 2, 2003·Annals of Neurology·S Claiborne JohnstonHarold P Adams

❮ Previous
Next ❯

Citations

Jan 29, 2005·Current Neurology and Neuroscience Reports·Mai N Nguyen-Huynh, S Claiborne Johnston
Apr 26, 2006·Current Treatment Options in Cardiovascular Medicine·Andrew M Demchuk
Jan 16, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S AslanyanK R Lees
Dec 4, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K-S HongB-C Lee
Jan 12, 2007·Current Opinion in Neurology·Shyam Prabhakaran
Feb 10, 2006·Expert Review of Neurotherapeutics·Christian Weimar, Hans-Christoph Diener
May 29, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Naoko KumagaiTakenori Yamaguchi
Jun 26, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·James E SieglerSheryl Martin-Schild
Aug 11, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Nikola SpriggUNKNOWN TAIST Investigators
Jul 25, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·S Claiborne JohnstonYuko Palesch
Sep 23, 2008·Handbook of Clinical Neurology·Naomi L Ruff, S Claiborne Johnston
Nov 26, 2009·International Journal of Stroke : Official Journal of the International Stroke Society·M AliUNKNOWN VISTA investigators
Dec 13, 2005·Stroke; a Journal of Cerebral Circulation·Gabrielle G LeblancVladimir Hachinski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.