Postsurgical disparity in survival between African Americans and Caucasians with colonic adenocarcinoma

Cancer
Dominik AlexanderUpender Manne

Abstract

Studies of colorectal adenocarcinoma (CRC) indicate a higher mortality rate for African Americans compared with Caucasians in the United States. In the current study, the authors evaluated the racial differences in survival based on tumor location and pathologic stage between African-American patients and Caucasian patients who underwent surgery alone for CRC. All 199 African American patients and 292 randomly selected, non-Hispanic Caucasian patients who underwent surgery between 1981 and 1993 for first primary sporadic CRC at the University of Alabama-Birmingham (Birmingham, AL) or an affiliated Veterans Affairs hospital were assessed for differences in survival. None of these patients received preoperative or postoperative neoadjuvant or adjuvant therapy. Survival curves were generated using the Kaplan-Meier method, and hazard ratios with 95% confidence intervals (95% CI) were estimated from Cox proportional hazards models, adjusting for demographic and tumor characteristics. African Americans were 1.67 (95% CI, 1.21-2.33) and 1.52 (95% CI, 1.12-2.07) times more likely to die of colonic adenocarcinoma (CAC) within 5 years and 10 years of surgery, respectively, compared with Caucasians. Racial differences in survival were obs...Continue Reading

References

Sep 1, 1988·Annals of Surgery·F MichelassiR Chappell
Jun 1, 1983·Diseases of the Colon and Rectum·R W BeartW M O'Fallon
Nov 15, 1995·Journal of the National Cancer Institute·R M MayberryM A Haynes
Oct 1, 1995·Archives of Family Medicine·K C ChuG A Alexander
Feb 1, 1994·International Journal of Epidemiology·S M GapsturA R Folsom
Jan 1, 1993·Current Problems in Cancer·R Bleday, W D Wong
Feb 20, 1996·International Journal of Cancer. Journal International Du Cancer·D S AlbertsB Levin
Jan 1, 1996·Nutrition and Cancer·P R HoltB S Reddy
Sep 1, 1996·Medical Care·J K Ball, A Elixhauser
Feb 1, 1997·American Journal of Epidemiology·M L SlatteryS L Edwards
Jan 1, 1997·Nutrition and Cancer·M L SlatteryJ D Potter
Mar 6, 1998·Annals of Surgery·G A PorterS C Newman
Jun 30, 2000·The New England Journal of Medicine·P A Jänne, R J Mayer
Nov 15, 2000·American Journal of Public Health·R G RoetzheimJ P Krischer
Apr 12, 2001·Journal of Clinical Epidemiology·S Marcella, J E Miller
Oct 10, 2001·The Journal of Pathology·E KapiteijnJ H van Krieken
May 2, 2002·Archives of Surgery·L James WudelSteven C Stain
May 17, 2002·Cancer·Harold P Freeman, Tarek A Alshafie
Jan 9, 2003·Cancer·Rangaswamy GovindarajanLaura F Hutchins
Feb 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James J DignamNorman Wolmark

❮ Previous
Next ❯

Citations

Feb 7, 2009·Journal of Psychosocial Oncology·Jamillah BerryChristopher Flowers
Apr 3, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Venkat R KatkooriUpender Manne
Nov 25, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Brooke E SylvesterOlufunmilayo I Olopade
Aug 13, 2009·World Journal of Gastroenterology : WJG·Anastasios DimouMuhammad Wasif Saif
Jun 26, 2009·Digestive Diseases and Sciences·Hassan AshktorabDuane Smoot
Aug 1, 2012·Radiology Research and Practice·Ioannis Z KapsalakisKostas N Fountas
Jun 1, 2005·The Medical Clinics of North America·Blase N PoliteOlufunmilayo I Olopade
Nov 23, 2006·Journal of the American College of Surgeons·Arden M MorrisJohn D Birkmeyer
Nov 23, 2005·The British Journal of Surgery·J T LeeS J Hollingsworth
Nov 9, 2010·American Journal of Surgery·Celia N RobinsonDavid H Berger
Jul 15, 2015·Journal of the National Cancer Institute·Harry H YoonUNKNOWN Alliance for Clinical Trials in Oncology
Dec 3, 2014·Journal of the American College of Surgeons·Sandy H FangSteven D Wexner
May 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Blase N PoliteOlufunmilayo I Olopade
Dec 1, 2009·Journal of Breath Research·Hany H EzzeldinRobert B Diasio
Apr 28, 2016·Oncotarget·Hassan AshktorabMehdi Nouraie
Jul 22, 2020·Ethnicity & Health·Fadi Abu BakerYael Kopelman
Jun 20, 2017·Current Colorectal Cancer Reports·Upender ManneEsther A Suswam
Sep 27, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lori Kay MattisonRobert B Diasio
Aug 19, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Hoa LeJason A Zell
Jan 26, 2021·Cancer Control : Journal of the Moffitt Cancer Center·Wentao WuJun Lyu
Nov 13, 2017·The American Journal of Pathology·Gaius J Augustus, Nathan A Ellis
Dec 8, 2009·Surgery·Melissa M MurphyShimul A Shah
Jun 10, 2021·JNCI Cancer Spectrum·Seohyuk LeeCharles S Fuchs

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.