Postsurgical inflammatory response is not associated with increased serum cystatin C values

Clinical Biochemistry
Torbjörn AkerfeldtAnders Larsson

Abstract

Cystatin C is used both as a glomerular filtration (GFR) marker and a cardiovascular risk marker. There are several studies showing an association between cystatin C and inflammatory markers and it has been suggested that the inflammatory response in itself could result in elevated cystatin C levels. The aim of this study was to evaluate if an induced inflammatory response has an effect on cystatin C levels in humans. CRP and cystatin C were analyzed in serum samples from orthopedic surgery patients (n=29). The patients were sampled prior to surgery and four and thirty days after surgery. The surgery induced a pronounced CRP elevation on day four, median 137.3 (interquartile range 104.1-178.2) mg/L compared to 1.94 (1.20-8.70) mg/L before surgery, P<0.001, but no significant difference in cystatin C levels before and four and thirty days after surgery could be seen. The orthopedic surgery-induced inflammatory response does not cause changes in cystatin C levels.

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Citations

Jan 22, 2011·Scandinavian Journal of Clinical and Laboratory Investigation·Torbjörn Akerfeldt, Anders Larsson
Mar 17, 2021·Scientific Reports·Johanna Helmersson-KarlqvistAnders Larsson

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