Postsynaptic alpha 2-adrenoceptors mediate pressor responses to 2-N,N-dimethylamino-5,6-dihydroxy-1,2,3,4-tetrahydronaphthalene (M-7)

European Journal of Pharmacology
G M Drew

Abstract

M-7 (2-N,N-dimethylamino-5,6-dihydroxy-1,2,3,4-tetrahydronaphthalene) is a potent agonist at presynaptic alpha 2-adrenoceptors in the pithed rat heart, it is also a potent vasopressor agent. The pressor effects of M-7 were unaffected by prazosin in doses much higher than were required to antagonise the pressor effects of phenylephrine, but were antagonised by yohimbine in doses lower than were effective against phenylephrine. The results suggest that the pressor responses to M-7 are mediated via postsynaptic alpha 2-adrenoceptors.

References

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Citations

Jun 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·G M Drew
Jul 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·R R RuffoloJ S Horng
Dec 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·P B TimmermansP A van Zwieten
Dec 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·N B Shepperson, S Z Langer
Apr 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·R A MaciaR M DeMarinis
May 18, 1984·European Journal of Pharmacology·P B TimmermansP A Van Zwieten
Jan 13, 1984·European Journal of Pharmacology·P B TimmermansP A Van Zwieten
May 1, 1985·Pharmacology, Biochemistry, and Behavior·R R Ruffolo
Feb 12, 1997·European Journal of Pharmacology·C Vayssettes-CourchayT J Verbeuren
Mar 1, 1981·Journal of Autonomic Pharmacology·H E ConnorP E Hicks
Jan 1, 1986·Hypertension·H Gavras
Jun 1, 1987·Drug Intelligence & Clinical Pharmacy·W D BernardJ O Covinsky
Mar 1, 1981·Journal of Autonomic Pharmacology·P B Timmermans, P A van Zwieten
Oct 1, 1989·Medicinal Research Reviews·J C McGrathV G Wilson

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