PMID: 6167815Jul 1, 1981Paper

Postsynaptic alpha-adrenoceptor subtypes in rabbit blood vessels and rat anococcygeus muscle studied in vitro

Journal of Cardiovascular Pharmacology
J R Docherty, K Starke

Abstract

Postsynaptic alpha-adrenoceptor subtypes were investigated in vitro, employing rabbit aorta, pulmonary artery, and portal vein, and rat anococcygeus. Phenylephrine (alpha 1-selective), alpha-methylnoradrenaline (mixed agonist), and xylazine (alpha 2-selective) were used as agonists, and prazosin (alpha 1-selective) and rauwolscine (alpha 2-selective) as antagonists. In all tissues, agonist concentration-response curves were monophasic and their shape was unaltered by either antagonist. In rabbit blood vessels, prazosin was as potent against alpha-methylnoradrenaline as against phenylephrine and was 1,000 times more potent than rauwolscine; xylazine was a partial agonist of low potency. Hence, the postsynaptic receptors of these tissues are alpha 1. In the rat anococcygeus, there was some evidence for an alpha 2-receptor: xylazine was a full and potent agonist, rauwolscine was more potent against xylazine than against alpha-methylnoradrenaline or phenylephrine, and in experiments protecting against irreversible blockade by phenoxybenzamine, xylazine afforded significantly greater protection to alpha-methylnoradrenaline than to phenylephrine. However, prazosin was more potent than rauwolscine against xylazine and was equipotent a...Continue Reading

Citations

Dec 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·T ShojiT Shigei
Dec 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·N B Shepperson, S Z Langer
Apr 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·R A MaciaR M DeMarinis
Aug 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·N B SheppersonS Z Langer
Aug 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·J R DochertyK Starke
Jan 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·I Lues, H J Schümann
Jul 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·T Hölting, K Starke
Jul 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·F Konno, I Takayanagi
Jan 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·K HondaK Shiono
Feb 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·M Gerold, G Haeusler
Jan 1, 1990·Journal of Neural Transmission. General Section·E VilaA Badia
Jul 18, 1989·European Journal of Pharmacology·G Haeusler, J E De Peyer
Oct 6, 1992·European Journal of Pharmacology·A AleixandreM Puerro
Oct 8, 2003·Toxicon : Official Journal of the International Society on Toxinology·Cleber E TeixeiraEdson Antunes
Apr 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·C E Bryant, K W Clarke
Jul 1, 1983·Clinical and Experimental Pharmacology & Physiology·I C Medgett, M W McCulloch
May 1, 1984·Clinical and Experimental Pharmacology & Physiology·T KatsuragiT Furukawa
Feb 1, 1992·Clinical and Experimental Pharmacology & Physiology·M J Rand, C G Li
Apr 1, 1991·British Journal of Pharmacology·I AkersA T Sullivan
Apr 1, 1992·The Journal of Pharmacy and Pharmacology·R A Lefebvre
Dec 1, 1994·Pharmacology & Toxicology·O A Nedergaard, J Møller
Nov 1, 1993·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·I T Uzbay, R Onur
May 1, 1983·Experimental Eye Research·D A LeeP M Vanhoutte
Sep 1, 1986·British Journal of Pharmacology·J R Docherty, L Hyland
Feb 1, 1988·British Journal of Pharmacology·C M BrownV G Wilson
Jul 1, 1983·British Journal of Pharmacology·K G Digges, R J Summers

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.