PMID: 6965526Mar 6, 1980Paper

Postsynaptic effects of ethanol at the frog neuromuscular junction

Nature
R J BradleyR Sterz

Abstract

The molecular mode of action of alcohol in the central nervous system (CN) is unclear. The effects of ethanol on axonal action potentials can only be measured at concentrations which are very much higher than those required to produce central effects. At the frog neuromuscular junction similar concentrations increase the open time (tau) of the ion channel associated with the nicotinic acetylcholine (ACh) receptor. We have now investigated the effect of ethanol on the postsynaptic membrane of the frog neuromuscular junction by measuring equilibrium dose-response curves for the interaction between the neuro-transmitter (ACh) and the ACh receptors. Using this system, we found that ethanol produces significant changes in receptor function. Moreover, we found that an ethanol concentration which can be physiologically tolerated by man (0.2%) the dose-response curve is measurably affected.

References

Jan 1, 1979·Annual Review of Pharmacology and Toxicology·S H Roth
Jan 1, 1976·Cold Spring Harbor Symposia on Quantitative Biology·K PeperK D Müller
Apr 22, 1974·Pflügers Archiv : European journal of physiology·F Dreyer, K Peper
Aug 1, 1972·The Journal of Physiology·B Katz, R Miledi

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Citations

Feb 1, 1984·Pflügers Archiv : European journal of physiology·W Finger, H Stettmeier
Oct 15, 1986·Brain Research·R SterzR J Bradley
Jun 4, 1982·European Journal of Pharmacology·R SterzR J Bradley
Jan 1, 1981·Pharmacology & Therapeutics·H Kalant, N Woo
Aug 8, 2002·Tissue & Cell·Marcia Miranda TorrejaisN A Basso
Jul 16, 1999·Neurochemistry International·T NarahashiK Nagata
Mar 1, 1984·The Journal of General Physiology·T M LinderD M Quastel
Jul 15, 1986·European Journal of Biochemistry·F Hucho
Jun 1, 1995·Alcoholism, Clinical and Experimental Research·M PagalaD Grob
Sep 3, 1998·Alcoholism, Clinical and Experimental Research·M J EckardtB Tabakoff
Jan 1, 1991·Annals of the New York Academy of Sciences·Y AracavaE X Albuquerque
Dec 22, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Matthew J BarnesStephen R Stannard
Jan 1, 1989·Journal of Receptor Research·V A EterovicP A Ferchmin
Nov 18, 2004·Alcoholism, Clinical and Experimental Research·Yi ZuoToshio Narahashi
May 29, 2004·Alcoholism, Clinical and Experimental Research·Yi ZuoToshio Narahashi
Dec 11, 1989·Biochimica Et Biophysica Acta·S A FormanK W Miller
Jan 1, 1987·Annals of the New York Academy of Sciences·G R SigginsJ Rogers
Jan 1, 1981·Annals of the New York Academy of Sciences·K PeperR J Bradley
Oct 16, 2014·Neuropharmacology·Stuart A FormanKeith W Miller
Feb 27, 2003·The Journal of Pharmacology and Experimental Therapeutics·Yi ZuoToshio Narahashi

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