Postsynaptic GABAB Rs Inhibit L-Type Calcium Channels and Abolish Long-Term Potentiation in Hippocampal Somatostatin Interneurons

Cell Reports
Sam A BookerImre Vida

Abstract

Inhibition provided by local GABAergic interneurons (INs) activates ionotropic GABAA and metabotropic GABAB receptors (GABABRs). Despite GABABRs representing a major source of inhibition, little is known of their function in distinct IN subtypes. Here, we show that, while the archetypal dendritic-inhibitory somatostatin-expressing INs (SOM-INs) possess high levels of GABABR on their somato-dendritic surface, they fail to produce significant postsynaptic inhibitory currents. Instead, GABABRs selectively inhibit dendritic CaV1.2 (L-type) Ca2+ channels on SOM-IN dendrites, leading to reduced calcium influx and loss of long-term potentiation at excitatory input synapses onto these INs. These data provide a mechanism by which GABABRs can contribute to disinhibition and control the efficacy of extrinsic inputs to hippocampal networks.

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Citations

Aug 8, 2018·Cell and Tissue Research·Sam A Booker, Imre Vida
Nov 20, 2019·Autism Research : Official Journal of the International Society for Autism Research·Weicheng DuanBo Xiong
Sep 16, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaoxu ZengLixue Chen
Jan 31, 2020·Molecular Brain·André KougioumoutzakisJean-Claude Lacaille
Sep 26, 2020·Frontiers in Cellular Neuroscience·Mari Paz Serrano-RegalMaría Victoria Sánchez-Gómez
Sep 2, 2020·European Journal of Pharmacology·Maciej KorczakMagdalena Bujalska-Zadrożny
May 15, 2021·Journal of Nutrition and Metabolism·Demetra J Mills
May 18, 2021·Neuropharmacology·Sam A Booker, David J A Wyllie
Jun 22, 2021·Frontiers in Neural Circuits·Eve HonoréJean-Claude Lacaille

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