PMID: 2905225Jan 1, 1988Paper

Postsynaptic modulation of cholinergic transmission by endogenous substances

Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology
T AkasuT Tokimasa


1. Recent concept of postsynaptic modulation is reviewed on the basis of literature data and the results of our investigation using conventional intracellular and voltage-clamp recording methods, in vitro. 2. Experimental evidence provided that the sensitivity of nicotinic ACh receptors endowed on the postsynaptic membrane of the bullfrog sympathetic ganglia and of the frog skeletal muscle end-plate is either facilitated or inhibited by other neurotransmitters or neurohormones. 3. We propose that one neurotransmitter not only initiates its own postsynaptic potential but also regulates the efficacy of synaptic transmission mediated by a distinct neurotransmitter, as an endogenous "antagonist" or "sensitizer".


Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·Y N JanS W Kuffler
May 15, 1979·European Journal of Pharmacology·H Van Wilgenburg
Jan 1, 1986·The Kurume Medical Journal·T AkasuM Tsurusaki
May 1, 1985·British Journal of Pharmacology·M AriyoshiT Tokimasa
Jun 1, 1968·European Journal of Pharmacology·F ColomoE Stefani
May 1, 1971·British Journal of Pharmacology·B L Ginsborg, G D Hirst
Nov 1, 1969·British Journal of Pharmacology·J L Laity
Jan 1, 1984·The Kurume Medical Journal·K KoketsuT Akasu
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M R Matthews, A C Cuello
Dec 1, 1983·Journal of the Autonomic Nervous System·C J DalsgaardG J Dockray
Feb 1, 1984·The Journal of Physiology·D E Clapham, E Neher
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·Y N JanS W Kuffler
Jul 23, 1984·Brain Research·Y OhtaK Koketsu
Mar 25, 1982·Brain Research·K KoketsuT Akasu
Oct 1, 1963·The Journal of Physiology·J C ECCLESW D WILLIS
Dec 1, 1964·Comparative Biochemistry and Physiology·S HAGIWARAK NAKA

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Jan 1, 1991·Neir̆ofiziologiia = Neurophysiology·R A GiniatullinS F Oshchepkova
Mar 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P HyllandP L Lutz
Jan 1, 1994·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H SoreqH Zakut

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