Postsynaptic Neurotransmitter Receptor Reserve Pools for Synaptic Potentiation

Trends in Neurosciences
Matthias Kneussel, Torben J Hausrat

Abstract

At excitatory and inhibitory synapses, an immediate transfer of additional neurotransmitter receptors from non-synaptic positions to the synapse mediates synaptic long-term potentiation (LTP). Different types of non-synaptic reserve pools permit the rapid supply of transmembrane neurotransmitter receptors. Recycling endosomes (REs) serve as an intracellular reservoir of receptors that is delivered to the plasma membrane on LTP induction. Furthermore, AMPA receptors at the non-synaptic plasma membrane provide an extrasynaptic reserve pool that is also important to potentiate synapse function. Finally, bidirectional synaptic versus extrasynaptic trapping of freely diffusing plasma membrane GABAA receptors (GABAARs) by scaffolding proteins modulates synaptic transmission. Here we discuss novel findings regarding neurotransmitter receptor reservoirs and potential reserve pool mechanisms for synaptic potentiation.

References

Feb 18, 1972·Science·S J Singer, G L Nicolson
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Feb 7, 1998·Science·P M LledoR A Nicoll
Jun 7, 2002·Nature·Aren J Borgdorff, Daniel Choquet
Oct 24, 2002·The Journal of Biological Chemistry·Chadwick M HalesJames R Goldenring
Aug 16, 2003·Developmental Cell·David D TranRichard J Bram
Sep 13, 2003·The EMBO Journal·Catherine TardinDaniel Choquet
Oct 15, 2003·Neuron·David S Bredt, Roger A Nicoll
Aug 24, 2004·Nature Neuroscience·Bence RáczRichard J Weinberg
Sep 28, 2004·Science·Mikyoung ParkMichael D Ehlers
Sep 29, 2004·Neuron·Robert C Malenka, Mark F Bear
Nov 20, 2004·Nature Reviews. Neuroscience·Graham L CollingridgeYu Tian Wang
Dec 18, 2004·Neuron·Rosalina FonsecaTobias Bonhoeffer
Mar 18, 2005·Molecular Biology of the Cell·Qing YanAndrew J Bean
May 25, 2005·The Journal of Comparative Neurology·Rong-Wen LiAngel L de Blas
Jun 14, 2005·Nature Neuroscience·Philip ThomasTrevor G Smart
Oct 14, 2005·Nature Neuroscience·Nathalie RouachRoger A Nicoll
Oct 5, 2006·Cell·Michael A Sutton, Erin M Schuman
Oct 21, 2006·Biochemical Society Transactions·J G Hanley
Oct 12, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Guillermo A YudowskiMark von Zastrow
Dec 28, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kurt C MarsdenReed C Carroll
Mar 4, 2008·Nature Neuroscience·Susana S CorreiaJosé A Esteban
Apr 12, 2008·Science·Martin HeineDaniel Choquet
Apr 22, 2008·Molecular and Cellular Neurosciences·Xu YuanBernhard Luscher
Mar 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marianne RennerAntoine Triller
Jun 2, 2009·Nature Neuroscience·Renato FrischknechtEckart D Gundelfinger

❮ Previous
Next ❯

Citations

May 21, 2016·Frontiers in Synaptic Neuroscience·Lenka Schorova, Stéphane Martin
Jul 19, 2016·Journal of Neurochemistry·Miranda MeleCarlos B Duarte
Nov 29, 2016·Nature Chemical Biology·Hans Michael MaricKristian Strømgaard
Dec 8, 2016·Behavioural Pharmacology·Alfredo Meneses
Mar 28, 2017·Reviews in the Neurosciences·Alfredo Meneses
Jan 6, 2018·Cellular and Molecular Life Sciences : CMLS·Binglin ZhuGuojun Chen
Dec 21, 2018·Frontiers in Molecular Neuroscience·Gabrielle T Parkinson, Jonathan G Hanley
Oct 1, 2020·Neuroscience Bulletin·Xing-Lei SongTian-Le Xu
Aug 10, 2019·Frontiers in Synaptic Neuroscience·Stephen D GlasgowEdward S Ruthazer
May 8, 2019·Addiction Biology·Douglas J Roberts-WolfePeter W Kalivas
Oct 22, 2020·IScience·Peter VerstraelenWinnok H De Vos
Oct 28, 2020·Scientific Reports·Sonia Vazquez-SanchezJan R T van Weering
Feb 25, 2021·Proceedings of the National Academy of Sciences of the United States of America·Chungwon ParkHyokeun Park
Mar 23, 2021·PLoS Computational Biology·Moritz F P Becker, Christian Tetzlaff
May 18, 2021·The Journal of Cell Biology·Yolanda GutiérrezJosé A Esteban

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Berton A Earnshaw, Paul C Bressloff
Current Opinion in Neurobiology
Patricio OpazoDaniel Choquet
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Loreto CuitinoNibaldo C Inestrosa
© 2021 Meta ULC. All rights reserved