Postsynaptic scaffolding molecules modulate the localization of neuroligins

Neuroscience
Joshua N LevinsonShernaz X Bamji

Abstract

Previous work has shown an important role for neuroligins in promoting the formation of synaptic connections in cultured cells. Although neuroligins enhance both excitatory and inhibitory synapse formation, individual neuroligin isoforms have been shown to preferentially localize to either glutamatergic or GABAergic synapses. Current evidence points to an important role for both the extracellular and intracellular domains of neuroligins in their synaptic localization. Although postsynaptic density protein 95 (PSD-95) has been shown to be involved in the recruitment of neuroligin 1 to excitatory synapses, the localization of neuroligin 2 (NL2) and neuroligin 3 (NL3) to excitatory and inhibitory synapses is less well defined. We assessed the roles of gephyrin and PSD-95, postsynaptic scaffolding molecules exclusively localized to inhibitory and excitatory synapses, respectively, in localizing NL2 and NL3 in primary neuronal cultures. We demonstrate that knockdown of gephyrin results in a significant shift of NL2 from inhibitory to excitatory synaptic contacts, while knockdown of PSD-95 leads to a partial shift of NL2 and NL3 from excitatory to inhibitory contacts. Furthermore, analysis of specific domain deletions within the C-te...Continue Reading

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Citations

Nov 1, 2011·Molecular Neurobiology·David KnightGabrielle L Boulianne
Nov 9, 2010·The Journal of Biological Chemistry·Mytyl AigaShernaz X Bamji
Apr 22, 2011·The Journal of Biological Chemistry·Zeynep Kasap VarleyPaola Zacchi
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Aug 4, 2021·Advanced Healthcare Materials·Cara T MotzCheng Zhu
Sep 21, 2021·Human Molecular Genetics·Nicholas J F GatfordDeepak P Srivastava

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