Postsynaptic serotonergic activity in depressive patients: evaluation of the neuroendocrine strategy

Psychiatry Research
H G WestenbergJ H Thijssen

Abstract

The possible occurrence of hypersensitive postsynaptic serotonin (5-hydroxytryptamine; 5-HT) receptors in depressive patients was investigated using a neuroendocrine strategy: determination of neuroendocrine parameters after activation of the serotonergic system. Activation was achieved by oral administration of l-tryptophan and l-5-hydroxytryptophan (5-HTP). The neuroendocrine parameters measured were the plasma concentrations of prolactin, growth hormone, thyroid stimulating hormone, and cortisol. Since administration of 5-HT precursors caused no significant change in the hormone concentrations, evaluation of neuroendocrine function after stimulation with 5-HT precursors does not appear to provide a reliable index of human postsynaptic serotonergic activity.

References

Apr 1, 1978·Psychoneuroendocrinology·A E Boyd, S Reichlin
Apr 1, 1978·Psychoneuroendocrinology·G M BrownP G Ettigi
Jul 1, 1977·The Journal of Clinical Endocrinology and Metabolism·P D Woolf, L Lee
Oct 1, 1977·Clinical Endocrinology·G A Smythe
Jan 1, 1977·The Journal of Clinical Endocrinology and Metabolism·A C EggeR M Blizzard
Feb 1, 1979·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·W M FraserW G Blackard
Jan 1, 1979·Psychoneuroendocrinology·M T HyyppäO Kytömäki
Dec 1, 1977·The Journal of Clinical Endocrinology and Metabolism·R H WiebeC B Hammond
Jan 1, 1973·The Journal of Clinical Endocrinology and Metabolism·H ImuraT Yoshimi
Aug 1, 1973·The Journal of Clinical Investigation·J H MacIndoe, R W Turkington
Apr 1, 1973·Endocrinologia Japonica·M YoshimuraT Hachiya
Jan 1, 1973·Folia Psychiatrica Et Neurologica Japonica·S TakahashiT Yoshimi
Mar 1, 1974·The Journal of Clinical Endocrinology and Metabolism·Y NakaiT Yoshimi
Apr 1, 1974·The Journal of Clinical Endocrinology and Metabolism·Y KatoS Ogo
Aug 1, 1971·The Journal of Clinical Endocrinology and Metabolism·C Faiman, J S Winter
Apr 1, 1970·Journal of Neurology, Neurosurgery, and Psychiatry·D EcclestonT B Crawford
Jul 1, 1966·The Journal of Clinical Endocrinology and Metabolism·T J MerimeeD Rabinowitz
Jan 1, 1981·Pharmacological Research Communications·L AnnunziatoP Preziosi
Jan 1, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·J H ThijssenA J Moolenaar

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Citations

Jan 1, 1992·Psychopharmacology·A T Veeninga, H G Westenberg
Jun 1, 1986·Biological Psychiatry·M IrwinA Yuwiler
Jan 1, 1987·Biological Psychiatry·H M van PraagR Kahn
Nov 11, 1983·European Journal of Pharmacology·A VaccariP S Timiras
Jan 1, 1993·Life Sciences·L N Yatham, M Steiner
Jan 1, 1992·Molecular Aspects of Medicine·A C Power, P J Cowen
Jul 1, 1987·Journal of Affective Disorders·M MaesE Suy
Oct 1, 1983·Psychiatry Research·H Y MeltzerM Lowy
Aug 1, 1984·Psychiatry Research·M H JosephP E Belchetz
Aug 1, 1992·Acta Psychiatrica Scandinavica·L StanerJ Mendlewicz
Jan 1, 1991·Progress in Neuro-psychopharmacology & Biological Psychiatry·M MaesJ Raus
Mar 23, 2002·Journal of Clinical Psychopharmacology·Harm J GijsmanAdam F Cohen
Jan 1, 1986·Suicide & Life-threatening Behavior·H M van Praag
Nov 1, 1986·Biological Psychiatry·H M van Praag

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