Postsynthetic Functionalization of DNA-Nanocomposites with Proteins Yields Bioinstructive Matrices for Cell Culture Applications.

Angewandte Chemie
Yong HuChristof M Niemeyer

Abstract

We report on the directed postsynthetic functionalization of soft DNA nanocomposite materials with proteins. Using the example of the functionalization of silica nanoparticle-modified DNA polymer materials with agonists or antagonists of the epidermal growth factor receptor EGFR cell membrane receptor, we demonstrate that hierarchically structured interfaces to living cells can be established. Owing to the modular design principle, even complex DNA nanostructures can be integrated into the materials, thereby enabling the high-precision arrangement of ligands on the lower nanometer length scale. We believe that such complex biohybrid material systems can be used for new applications in biotechnology.

References

Jul 11, 2006·Nature Reviews. Molecular Cell Biology·Ami Citri, Yosef Yarden
Jan 31, 2007·Journal of the American Chemical Society·Ryan C BaileyJames R Heath
Apr 14, 2007·Nature Reviews. Drug Discovery·Janice M Reichert, Viia E Valge-Archer
Aug 28, 2013·Journal of the American Chemical Society·Thua N N TranDan Luo
Feb 19, 2014·Current Opinion in Chemical Biology·Rebecca MeyerChristof M Niemeyer
Jun 3, 2014·Accounts of Chemical Research·Dayong YangDan Luo
Dec 8, 2015·Angewandte Chemie·Alessandro AngelinChristof M Niemeyer
Jan 14, 2016·Chemical Society Reviews·Juan LiWeihong Tan
Feb 12, 2017·Accounts of Chemical Research·Dong WangDan Luo
Mar 17, 2017·Accounts of Chemical Research·Yu ShaoDongsheng Liu
Feb 2, 2018·Advanced Materials·Yuezhou ZhangHongbo Zhang
Nov 16, 2018·Angewandte Chemie·Ann-Kathrin Schneider, Christof M Niemeyer
Feb 16, 2019·Advanced Materials·Yong Hu, Christof M Niemeyer

❮ Previous
Next ❯

Citations

Aug 11, 2021·Polymers·Alessa SchippergesChristof M Niemeyer

❮ Previous
Next ❯

Methods Mentioned

BETA
fluorescence microscopy
electrophoresis
Fluorescence

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.