Posttranscriptional control of airway inflammation

Wiley Interdisciplinary Reviews. RNA
Wendy Ezegbunam, Robert Foronjy

Abstract

Acute inflammation in the lungs is a vital protective response, efficiently and swiftly eliminating inciters of tissue injury. However, in respiratory diseases characterized by chronic inflammation, such as chronic obstructive pulmonary disease and asthma, enhanced expression of inflammatory mediators leads to tissue damage and impaired lung function. Although transcription is an essential first step in the induction of proinflammatory genes, tight regulation of inflammation requires more rapid, flexible responses. Increasing evidence shows that such responses are achieved by posttranscriptional mechanisms directly affecting mRNA stability and translation initiation. RNA-binding proteins, microRNAs, and long noncoding RNAs interact with messenger RNA and each other to impact the stability and/or translation of mRNAs implicated in lung inflammation. Recent research has shown that these biological processes play a central role in the pathogenesis of several important pulmonary conditions. This review will highlight several posttranscriptional control mechanisms that influence lung inflammation and the known associations of derangements in these mechanisms with common respiratory diseases. WIREs RNA 2018, 9:e1455. doi: 10.1002/wrn...Continue Reading

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Citations

Apr 5, 2019·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Ebrahim MazloomiShahram Shahabi
Jul 4, 2018·Infection and Immunity·Louis-Philippe LerouxMaritza Jaramillo
Oct 6, 2020·Frontiers in Pharmacology·Xueyi ZhuJingcheng Dong
Jun 11, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Zhenxing XuWei Guo
Oct 31, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Weifeng ZouPixin Ran

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