PMID: 6159624Jul 1, 1980Paper

Posttranscriptional regulation of an erythromycin resistance protein specified by plasmic pE194

Proceedings of the National Academy of Sciences of the United States of America
A G ShivakumarD Dubnau

Abstract

Induction of the synthesis of a plasmid-encoded polypeptide (E3) by erythromycin is known to be required for the inducible expression of resistance to the macrolide-lincosamide-streptogramin B group of antibiotics in Bacillus subtilis strains carrying the plasmid pE194. This resistance is mediated by a specific N6-dimethylation of adenine in the 23S rRNA of the large ribosomal subunit. We show in this report that E3 induction is regulated posttranscriptionally in the sense that it can occur when RNA synthesis is blocked and that induction is accompanied by an increase in the functional half-life of E3 mRNA but not of the mRNA species that code for the remaining four known pE194 polypeptides. The induction of E3 is subject to feedback regulation and involves the ribosome. Modification of the erythromycin binding site on the ribosome by methylation or by mutation interferes with induction.

References

Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A M FallonM Nomura
Jan 18, 1977·Molecular & General Genetics : MGG·D J TipperH G Wittmann
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·T J Gryczan, D Dubnau
Nov 25, 1978·Journal of Molecular Biology·G LemaireM Yarus
Aug 10, 1976·Molecular & General Genetics : MGG·E DubnauI Smith
Apr 1, 1977·Antimicrobial Agents and Chemotherapy·N E Allen
Jan 1, 1976·Antimicrobial Agents and Chemotherapy·S PestkaJ Unowsky
Oct 1, 1974·Antimicrobial Agents and Chemotherapy·S Pestka
Oct 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·A Bernardi, P F Spahr
Dec 14, 1972·Journal of Molecular Biology·S Hiraga, C Yanofsky
Jul 1, 1965·Journal of Molecular Biology·D Gillespie, S Spiegelman
Apr 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·C J Lai, B Weisblum

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Citations

Jan 1, 1982·Molecular & General Genetics : MGG·J HahnD Dubnau
Jan 1, 1980·Molecular & General Genetics : MGG·A G ShivakumarD Dubnau
Jan 1, 1984·Molecular & General Genetics : MGG·T J GryczanD Dubnau
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H C Wong, S Chang
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D H Bechhofer, D Dubnau
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·Z AlexievaP S Lovett
Jan 5, 2002·Microbiology and Immunology·H J YunE C Choi
Dec 19, 2007·Antimicrobial Agents and Chemotherapy·Marne BaileyAlexander S Mankin
Apr 1, 1995·Antimicrobial Agents and Chemotherapy·B Weisblum
Jun 10, 2003·Microbiology and Molecular Biology Reviews : MMBR·Ciarán Condon
Jul 1, 1981·Plasmid·J Scheer-AbramowitzD Dubnau
Nov 10, 2006·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·B Weisblum
Nov 19, 2013·Molecular Cell·Pulkit GuptaNora Vázquez-Laslop
Apr 29, 2008·Molecular Cell·Nora Vazquez-LaslopAlexander S Mankin
Feb 14, 2009·Progress in Molecular Biology and Translational Science·David H Bechhofer
Jun 26, 1990·Biochemistry·S L Su, D Dubnau
Mar 1, 1993·Molecular Microbiology·J F DiMari, D H Bechhofer
Sep 1, 1990·Molecular Microbiology·D H Bechhofer
Nov 29, 2013·Nature·John F Atkins, Pavel V Baranov
Mar 1, 1997·FEMS Microbiology Letters·M MatsuokaY Nakajima
Oct 6, 2020·Frontiers in Microbiology·Diego A Vargas-Blanco, Scarlet S Shell
Feb 13, 2003·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Toshiko Aiso, Reiko Ohki
Jan 26, 2002·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yoshinori Nakajima
May 16, 2021·Nature Communications·Maxim S SvetlovAlexander S Mankin
Nov 1, 1989·Journal of Bacteriology·D H Bechhofer, K H Zen
Sep 1, 1992·Journal of Bacteriology·K K Hue, D H Bechhofer
Mar 1, 1997·Journal of Bacteriology·S S ChoiE C Choi
Nov 1, 1982·Journal of Bacteriology·T J GryczanD Dubnau

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