PMID: 8587656Aug 1, 1995Paper

Posttranscriptional regulation of H1 zero and H3.3B histone genes in differentiating rat cortical neurons

Neurochemical Research
M ScaturroItalia Di Liegro

Abstract

Accumulation of mRNAs encoding H1 zero and H3.3, two histone replacement variants, was studied in differentiating cortical neurons, cultured in a serum-free medium, with or without triiodothyronine (T3) supplementation. We found that the levels of both H1 (zero) and H3.3B mRNAs decrease in isolated neurons between the 2nd and 5th day of culture to the same extent as in vivo. At the same time, an active synthesis of the corresponding proteins was evidenced. The effects of transcription inhibition by actinomycin D and the results of nuclear run-on experiments suggest that H1 zero and H3.3 expression is regulated mainly at the posttranscriptional level. Concerning T3, only marginal effects were noticed, apart from up-regulation of both histone mRNAs at 2 days in culture. We propose one model for posttranscriptional regulation of the analyzed genes and discuss potential relationships to remodelling of chromatin.

References

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Citations

Jan 29, 2009·Journal of Proteome Research·Raghothama ChaerkadyAkhilesh Pandey
Apr 27, 2007·Annals of the New York Academy of Sciences·Kalliope E Sekeri-Pataryas, Thomae G Sourlingas
Jan 24, 2014·International Journal of Molecular Medicine·Carlo Maria Di LiegroItalia Di Liegro
Aug 26, 1998·The Journal of Biological Chemistry·M ScaturroI Di Liegro
May 28, 2003·Journal of Cellular and Molecular Medicine·Lavinia RaimondiItalia Di Liegro
Nov 16, 2010·Developmental Cell·Laura A BanaszynskiPeter W Lewis

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