Posttranscriptional regulation of uridine diphosphate glucuronosyltransferases

Expert Opinion on Drug Metabolism & Toxicology
Zoe Riches, Abby C Collier

Abstract

The uridine diphosphate (UDP)-glucuronosyltransferase (UGT) superfamily of enzymes (EC 2.4.1.17) conjugates glucuronic acid to an aglycone substrate to make them more polar and readily excreted. In general, this reaction terminates the activities of chemicals, drugs and toxins, although occasionally a more active or toxic species is produced. In addition to their well-known transcriptional responsiveness, UGTs are also regulated by posttranscriptional mechanisms. Here, the authors review these mechanisms, including latency, modulation of co-substrate accessibility and binding, dimerization and oligomerization, protein-protein interactions, allosteric inhibition and activation, posttranslational structural and functional modifications and developmental switching for UGTs. Posttranscriptional regulation of UGTs has traditionally received less attention than nuclear regulation, in part because mechanisms involving ribosomes and endoplasmic reticula are challenging to investigate. Most promising of the posttranscriptional mechanisms reviewed are likely to be effects on co-substrate (UDP-glucuronic acid) transport and availability and structure-function changes to UGT proteins through, for example, glycosylation and phosphorylation....Continue Reading

References

Apr 1, 1992·Biochemical Pharmacology·D Zakim, A J Dannenberg
Jan 1, 1989·Developmental Pharmacology and Therapeutics·B BurchellR Hume
Jan 1, 1980·Annals of the New York Academy of Sciences·R E McMahon
Sep 1, 1980·Tubercle·G Acocella, R Conti
Oct 11, 1996·Biochemical Pharmacology·M CsalaJ Mandl
Nov 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C Tiribelli, J D Ostrow
Dec 24, 1997·Clinical and Experimental Pharmacology & Physiology·R Meech, P I Mackenzie
Nov 11, 1998·General Pharmacology·F Guéraud, A Paris
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·D W HumS Dubois
Nov 27, 1999·Drug Metabolism Reviews·A Radominska-PandyaP I Mackenzie
Dec 22, 1999·Current Opinion in Chemical Biology·B Imperiali, S E O'Connor
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·R H Tukey, C P Strassburg
Jun 26, 2001·European Journal of Drug Metabolism and Pharmacokinetics·M CappielloG M Pacifici
Sep 1, 2001·Biochimie·H H Freeze, V Westphal
Sep 5, 2001·Nature Cell Biology·S GotoS Hayashi
Dec 18, 2001·Seminars in Liver Disease·H H Freeze
Jan 5, 2002·Drug Metabolism Reviews·M B FisherS A Wrighton
Aug 16, 2002·Molecular Pharmacology·Robert H TukeyPeter I Mackenzie
Mar 21, 2003·Biochemical and Biophysical Research Communications·Nikhil K BasuIda S Owens
May 29, 2003·Current Drug Metabolism·P I MackenzieA Radominska-Pandya
Jun 20, 2003·The Pharmacogenomics Journal·C Guillemette
Sep 2, 2003·Biochemical Pharmacology·Karl Walter Bock
Aug 24, 2004·Molecular Pharmacology·Zhigang ZhangJin-Ming Yang
Sep 15, 2004·Toxicology and Applied Pharmacology·Philip A GregoryPeter I Mackenzie
Oct 16, 2004·Molecular Pharmacology·Jacqueline J FremontChristopher D King

❮ Previous
Next ❯

Citations

Oct 27, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Camille Girard-BockChantal Guillemette
Mar 15, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G KaurM Verma
Jan 7, 2017·Journal of Biomedical Science·Aishwarya NeneDaria Mochly-Rosen
Feb 13, 2020·British Journal of Cancer·Eric P AllainChantal Guillemette
May 27, 2021·Human Genomics·Cui-Lan MengDan-Ni Zhong
Sep 6, 2017·Molecular Pharmaceutics·Ming HuZhongqiu Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.