Posttransfusion non-A, non-B hepatitis: physicochemical properties of two distinct agents

The Journal of Infectious Diseases
D W BradleyH A Fields

Abstract

Two separate and distinct episodes of non-A, non-B hepatitis were induced in each of two chimpanzees by two inocula: one containing a chloroform-resistant agent and the other containing a chloroform-sensitive agent. Both agents were recovered from liver tissue and plasma obtained from a single chimpanzee during the acute and chronic phases of infection with a factor VIII concentrate, respectively. The chloroform-resistant agent did not cause unique changes in hepatocytes; in contrast, the chloroform-sensitive agent did induce the formation of cytoplasmic tubules, convoluted endoplasmic reticulum, and dense reticular inclusion bodies. The latter changes are similar in character to those induced in infected cells by some enveloped mammalian RNA viruses.

Citations

Jul 1, 1991·Journal of Medical Virology·D BradleyE H Cook
Mar 1, 1993·Journal of Medical Virology·K X LuoS Jiang
Apr 1, 1994·Journal of Medical Virology·T PetersJ Rasenack
Jan 1, 1992·Medical Microbiology and Immunology·R ThomssenA Uy
Jan 1, 1991·Archives of Virology·P G Plagemann
Apr 1, 1985·Journal of Virological Methods·D W Bradley
Apr 1, 1994·Journal of Virological Methods·P ParvazM Sepetjan
Jan 1, 1989·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A P Choksi, H G Desai
Mar 30, 1985·Lancet·E Tabor
Jun 17, 1998·Journal of Virological Methods·S L MelvinI K Mushahwar
Jun 1, 1995·Nature Medicine·J N SimonsI K Mushahwar
Jul 19, 1984·The New England Journal of Medicine·S M Feinstone, J H Hoofnagle
Nov 30, 1989·The New England Journal of Medicine·M J Alter, R E Sampliner
Sep 19, 1998·The New England Journal of Medicine·L E Prescott, P Simmonds
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·Y K ShimizuR H Purcell
Oct 19, 2001·Journal of Clinical Gastroenterology·M Aslam, J Aslam
Jan 1, 1990·Journal of Gastroenterology and Hepatology·H J Alter
Sep 1, 1991·Gut·J Y LauA Alberti
Jan 1, 1993·Gut·H Schmilovitz-WeissG Dusheiko
Jun 1, 1990·Journal of Clinical Pathology·J C Underwood
Aug 1, 1991·Postgraduate Medical Journal·P M HarrisonR Williams
Jun 21, 2011·Annual Review of Microbiology·Catherine L Murray, Charles M Rice
Sep 1, 1990·Baillière's Clinical Gastroenterology·N Sheron, G J Alexander
Apr 1, 1992·Transfusion Medicine Reviews·D W Bradley
Feb 12, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Michael Houghton

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