Posttransfusion recovery of stored red blood cells in very low birth weight infants using a hemoglobin balance model

Transfusion
Anne Grete BechensteenJohn A Widness

Abstract

A Hb balance model was used in very low birth weight (VLBW) infants to predict posttransfusion Hb levels from which we inferred allogeneic RBC recovery after transfusion of RBCs stored for varying periods of time. Premature VLBW infants receiving RBC transfusions during the 1st month of life were evaluated retrospectively for RBC survival of stored donor blood. Actual Hb levels measured in infant blood 1 and 2 days after RBC transfusions were compared to those predicted using a Hb balance model based on factors affecting blood Hb loss and gain. Transfusions were subgrouped according to whether or not infants were clinically stable at the time of RBC transfusion. Model-predicted RBC recovery was also evaluated relative to duration of RBC storage. Model-predicted mean (+/- SD) Hb levels 2 days after transfusion among the 30 VLBW infants receiving a total of 57 RBC transfusions were only 4 percent higher than actual values observed (15.2 +/- 1.2 g/dL vs. 14.7 +/- 1.4, respectively; p < 0.05). The infant's clinical status at the time of transfusion did not affect predicted 1- and 2-day posttransfusion RBC recovery. Model-predicted recovery of transfused RBCs was modestly, but significantly, decreased with increasing duration of don...Continue Reading

References

Oct 1, 1982·The Journal of Pediatrics·M J HumphreyJ J Corrigan
May 1, 1994·Archives of Disease in Childhood. Fetal and Neonatal Edition·I M Wright, S R Goodall
Feb 1, 1994·Archives of Disease in Childhood·J E Wright, H L Butt
Jul 1, 1997·Pediatric Research·H Bard, J A Widness
Aug 5, 1997·Transfusion Science·I Chin-YeeM S d'Almeida
Aug 2, 2000·Pediatrics·J C LinJ A Widness

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Citations

Feb 17, 2007·Transfusion·Patrick DaviesPeter Davis

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