Posttranslational Amelogenin Processing and Changes in Matrix Assembly during Enamel Development

Frontiers in Physiology
Mirali PandyaT G H Diekwisch

Abstract

The extracellular tooth enamel matrix is a unique, protein-rich environment that provides the structural basis for the growth of long and parallel oriented enamel crystals. Here we have conducted a series of in vivo and in vitro studies to characterize the changes in matrix shape and organization that take place during the transition from ameloblast intravesicular matrices to extracellular subunit compartments and pericrystalline sheath proteins, and correlated these changes with stages of amelogenin matrix protein posttranslational processing. Our transmission electron microscopic studies revealed a 2.5-fold difference in matrix subunit compartment dimensions between secretory vesicle and extracellular enamel protein matrix as well as conformational changes in matrix structure between vesicles, stippled materials, and pericrystalline matrix. Enamel crystal growth in organ culture demonstrated granular mineral deposits associated with the enamel matrix framework, dot-like mineral deposits along elongating initial enamel crystallites, and dramatic changes in enamel matrix configuration following the onset of enamel crystal formation. Atomic force micrographs provided evidence for the presence of both linear and hexagonal/ring-sh...Continue Reading

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Citations

Jun 26, 2020·Advanced Materials·Dong WangPeng Yang
Mar 19, 2020·Stem Cells International·Geraldine M AhmedKarim Fawzy El-Sayed
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Feb 15, 2019·ACS Nano·Jacob R JokisaariThomas G H Diekwisch
Aug 27, 2021·ACS Biomaterials Science & Engineering·Wen QinLi-Na Niu

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Methods Mentioned

BETA
imaging techniques
light
transmission
atomic
nuclear magnetic resonance
atomic force microcroscopy
dynamic light scattering
light scattering
X-ray
electron microscopy

Software Mentioned

Genescript

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