PMID: 8594315Jan 1, 1996Paper

Posttranslational changes in band 3 in adult and aging brain following treatment with ergoloid mesylates, comparison to changes observed in Alzheimer's disease

Life Sciences
C CoverM M Kay

Abstract

Band 3, the most heavily used anion transport system in vertebrates, ages as cells and tissues age. Posttranslational changes in band 3 in adult and aging brain were investigated following treatment with ergoloid mesylates and compared to changes observed in Alzheimer's disease (AD). The study was conducted in a double blind fashion and was decoded only after the study was completed. The following posttranslational changes in brain band 3 occur with age: increased breakdown of band 3; decreased phosphorylation; and decreased anion transport. Autoantibodies to senescent cell antigen (SCA) synthetic peptides residue 538-554 and 812-827 increase with age, but antibodies to the former peptide are significantly reduced in ergoloid mesylate treated old mice. This is a critical transport region of band 3. Results showed the aged/altered band 3 increased in Alzheimer's disease (AD) as determined by quantitative antibody binding. Ergoloid mesylates altered the age-related posttranslational changes as follows: the observed age-related decrease in brain band 3 was partially reversed and anion transport was increased. This is consistent with the data indicating decreased autoantibodies to a critical anion transport segment of band 3. Aging...Continue Reading

References

Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M M Kay
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M M KayS F Schluter
Jul 1, 1991·Transfusion Medicine Reviews·M M KayG Bosman
Jan 1, 1991·Annals of the New York Academy of Sciences·M M Kay
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M M KayF B Lin
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M M KayG Bosman
Jan 1, 1988·Annals of the New York Academy of Sciences·M M KayP Coleman
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M M KayP S Bassel
May 31, 1994·Annals of the New York Academy of Sciences·M M KayJ Goodman

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Citations

May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·J E PoulinM B Kay
May 21, 2014·Clinical Hemorheology and Microcirculation·Cristiana Carelli-AlinoviFrancesco Misiti
Dec 18, 2002·Journal of Neuropathology and Experimental Neurology·Thor D SteinRonald E Kalil
Oct 3, 2001·Physiological Reviews·D Markovich
Aug 26, 2021·Patterns·Shuting JinXiangxiang Zeng

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