Posttranslational Processing and Function of Mucosal Maltases

Journal of Pediatric Gastroenterology and Nutrition
Mahdi Amiri, Hassan Y Naim

Abstract

The final step of carbohydrate digestion in the intestine is performed by 2 major α-glucosidases of the intestinal mucosa, sucrase-isomaltase (SI) and maltase-glucoamylase. Both of these enzymes are type II membrane glycoproteins, which share a significant level of homology in gene and protein structures and yet have differences in the posttranslational processing, substrate specificity and functional capacity. Insufficient activity of these disaccharidases particularly SI as a result of genetic mutations or secondary intestinal pathologies is associated with carbohydrate maldigestion and gastrointestinal intolerances. This review will discuss the maturation profiles of SI and maltase-glucoamylase relative to their functional capacities and deficiencies.

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Citations

Feb 7, 2020·Animal : an International Journal of Animal Bioscience·D L Harmon, K C Swanson
Jun 10, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Ninna Karsbæk SenftleberMarit Eika Jørgensen

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