PMID: 11216761Feb 24, 2001Paper

Posttransplant function of a nonbeating heart is predictable by an ex vivo perfusion method

The Annals of Thoracic Surgery
K SuehiroS Sano

Abstract

We attempted to predict the posttransplant cardiac function of nonbeating donor hearts. A total of 13 dogs were studied. Hearts were left in situ for 45 minutes after cardiac arrest caused by exsanguination. Hearts were then excised and reperfused in an ex vivo perfusion apparatus after 60 minutes of warm ischemia to test whether they could eject against an 80 mm Hg afterload from a preload of 10 mm Hg. Thereafter, all hearts were transplanted orthotopically. Four of 13 hearts were able to eject in the apparatus (group A). However, the other nine hearts could not eject under the defined conditions (group B). All four hearts in group A showed good posttransplant hemodynamics (systolic arterial pressure > 80 mm Hg with mean left atrial pressure < 10 mm Hg) without dopamine. However, none of nine hearts in group B could support the circulation without dopamine. Nonbeating donor heart function evaluated in the perfusion apparatus predicts posttransplant heart function. This method may be applicable for selection of transplantable hearts from nonbeating heart donors.

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Citations

Jun 10, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Michael J CollinsRobert S Poston
Mar 19, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Joevin SourdonSarah L Longnus
Apr 6, 2007·Biomedizinische Technik. Biomedical Engineering·Lutz PfeiferAndré Rex
Nov 14, 2002·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Makoto MohriShunji Sano
Oct 9, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ilhan InciWalter Weder
Apr 4, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Michael J CollinsRobert S Poston
Sep 1, 2015·Canadian Journal of Physiology and Pharmacology·Christopher W WhiteDarren Freed
Dec 3, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Christopher W WhiteDarren H Freed
Dec 9, 2008·Current Opinion in Organ Transplantation·Michael L CobertMichael E Jessen
Apr 9, 2010·Current Opinion in Anaesthesiology·Vito Fanelli, Luciana Mascia
Nov 28, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Bryan GellnerMitesh V Badiwala
Mar 1, 2018·Frontiers in Cardiovascular Medicine·Christopher W WhiteDarren H Freed
May 21, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Matthias FuchsMatthias Siepe
Apr 17, 2014·Nature Reviews. Cardiology·Sarah L LongnusHendrik T Tevaearai
Nov 10, 2020·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Lu WangJohn H Dark

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