Posttransplant lymphoproliferative disorder after umbilical cord blood transplantation in children

The American Journal of Surgical Pathology
Jerald Z GongPatrick J Buckley

Abstract

Reported are 7 cases of posttransplant lymphoproliferative disorder (PTLD) arising in children who received umbilical cord blood transplantation (UCBT). There were 4 females and 3 males with a median age of 3 years (range, 1-16 years). All 7 patients received UCBT, including 1 patient who received multiple units and 1 transplanted under nonmyeloablative condition. The time interval from UCBT to PTLD averaged 4 months (range, 2 weeks to 9 months). Patients typically presented with high-stage disease with visceral organ involvement. Histology of the PTLDs showed monomorphic morphology in 5 cases and polymorphic morphology in the remaining 2 cases. Bone marrow biopsies were performed in 3 cases and were negative for PTLD. Epstein-Barr virus (EBV) was detected in the PTLD in all 7 patients by in situ hybridization. Evidence of past EBV infection was found in the recipients, but the EBV genome was not detected in the donor cord blood samples, suggesting that donor cord blood was not the source of EBV infection. The origin of the PTLD was investigated in 5 cases. PTLD was of host origin in 2 patients who failed engraftment and of donor origin in the remaining 3 patients who had complete engraftment. Four of 5 patients with monomorphi...Continue Reading

Citations

Jun 30, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J StyczynskiP Ljungman
Apr 26, 2007·Vox Sanguinis·J-A van Burik, C G Brunstein
Feb 11, 2015·Tissue Engineering. Part a·David M KepecsRichard E Gilbert
Nov 30, 2006·Blood·Catherine M Flynn, Dan S Kaufman

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