Posttransplant Lymphoproliferative Disorder in a Patient with Worsening Ascites after Liver Transplantation

Case Reports in Hematology
Harsh D Patel, Moises I Nevah Rubin

Abstract

Posttransplant lymphoproliferative disorder (PTLD) is a spectrum of diseases that involves abnormal lymphoid and/or plasmacytic proliferation in patients with solid organ or hematopoietic cell transplantation. It is a condition with a low incidence of 3.5-4.3% in liver transplant (LT) recipients. This case involves a 63-year-old male with history of LT for chronic HCV induced cirrhosis who presented with abdominal distension related to worsening ascites. Cytological ascitic fluid analysis revealed EBV (+) malignant cells without a malignant focal point on imaging. Diagnosis of monomorphic PTLD with primary effusion lymphoma-like morphology and immunophenotype was established. This case highlights the complexity in diagnosis, different diagnostic modalities, and rare clinical presentations of PTLD.

References

Dec 20, 1990·The New England Journal of Medicine·I Penn
Jun 1, 1997·Diagnostic Cytopathology·D DusenberyS H Swerdlow
Dec 18, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Rami T BustamiFriedrich K Port
Jun 1, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·David G KochAdrian Reuben

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Methods Mentioned

BETA
biopsy
flow cytometry

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