Abstract
Posttransplant lymphoproliferative disorder (PTLD) is a well-known complication of both solid organ and bone marrow transplantation. It includes a wide spectrum of proliferative changes ranging from reactive hyperplasia, borderline lesions to malignant lymphomas. PTLD develops in 1% to 10% of transplant recipients. We present 10 cases of PTLD. Five developed after renal, four after liver, and one after heart transplantation. Among the early lesions, we diagnosed two reactive plasmacytic hyperplasias; one infectious mononucleosis-like PTLD; one polymorphic lesion; and one "mixed" case of plasmacytic hyperplasia in one tonsil with a polymorphic PTLD in the second one. Among the lymphomas, we observed three diffuse large B-cell lymphoma (DLBCL); one mantle lymphoma; and one Hodgkin lymphoma-like PTLD. The morphological pictures of six PTLD cases were typical and posed no diagnostic problems. In the one case of plasmacytic hyperplasia, the lymph node morphology was atypical with atrophy of lymphoid components accompanying plasma cell proliferation. Contrary to a good prognosis of early, reactive PTLD, this patient experienced a rapid course and succumbed to sepsis. The most difficult case was a rare Hodgkin lymphoma-like PTLD, whic...Continue Reading
References
May 1, 1995·Human Pathology·M A LonesJ W Said
Dec 12, 1997·The Journal of Infectious Diseases·R MañezM Ho
Feb 7, 1998·Journal of Hepatology·M McCarthyR Williams
Aug 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C HézodeD Dhumeaux
Feb 5, 2000·Nephron·M BustilloJ L Sastre
Mar 15, 2000·The American Journal of Surgical Pathology·B P NelsonS H Swerdlow
Mar 27, 2001·Transplantation Proceedings·G F RondinaraD Forti
Mar 29, 2001·International Journal of Cancer. Journal International Du Cancer·Y HoshidaK Aozasa
Jun 13, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·L M LarrattJ K Preiksaitis
Dec 17, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Vikas R DharnidharkaWilliam E Harmon
Jun 27, 2003·Transplantation Proceedings·R M LangerF Perner
Aug 5, 2003·Current Oncology Reports·Richard F Ambinder
Sep 10, 2003·Transplantation Proceedings·M J SolerJ Lloveras
Sep 10, 2003·Transplantation Proceedings·R MarcénJ Ortuño
Sep 10, 2003·Transplantation Proceedings·E RubioV Cuervas-Mons
Oct 8, 2003·Transplantation Proceedings·B Ziarkiewicz-WróblewskaA Wasiutyński
Apr 28, 2004·Transplantation Proceedings·A AlvarezE Vazquez-Martul
Oct 1, 2004·Medical Oncology·Stefan NorinHans Hägglund
Jan 25, 2005·Transplantation·Irene M GhobrialChristopher G McGregor
Citations
Mar 1, 2008·Journal of Crohn's & Colitis·Antonio López San RománAntonio Rey
Mar 22, 2012·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Hossein Khedmat, Saeed Taheri
Jun 26, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Krzysztof MuchaLeszek Paczek
Mar 1, 2012·Clinical Imaging·Faiq ShaikhRichard C Semelka
Nov 26, 2010·Transplantation Proceedings·A TestaF Del Nonno
Jan 18, 2014·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Aghil Gholipour-ShoiiliSaeed Taheri
Dec 6, 2011·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Ornella LeoneGayle L Winters
Jul 7, 2009·International Journal of Surgical Pathology·Smita KrishnamurthyFriederike H Kreisel
Dec 29, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Olga A TaylorBeth A Carter
Nov 26, 2009·Transplantation·Kareem M Abu-ElmagdMichael A Nalesnik
Sep 7, 2007·Annual Review of Entomology·Lawrence A Lacey, David I Shapiro-Ilan
Aug 28, 2014·Current Opinion in Oncology·Jaime Sanz, Rafael Andreu
Nov 23, 2016·Journal of Clinical Anesthesia·Fouad Ghazi SoukiErnesto A Pretto