Posttransplant lymphoproliferative disorders.

Advances in Hematology
Hazem A H Ibrahim, Kikkeri N Naresh

Abstract

Posttransplant lymphoproliferative disorders (PTLDs) are a group of diseases that range from benign polyclonal to malignant monoclonal lymphoid proliferations. They arise secondary to treatment with immunosuppressive drugs given to prevent transplant rejection. Three main pathologic subsets/stages of evolution are recognised: early, polymorphic, and monomorphic lesions. The pathogenesis of PTLDs seems to be multifactorial. Among possible infective aetiologies, the role of EBV has been studied in depth, and the virus is thought to play a central role in driving the proliferation of EBV-infected B cells that leads to subsequent development of the lymphoproliferative disorder. It is apparent, however, that EBV is not solely responsible for the "neoplastic" state. Accumulated genetic alterations of oncogenes and tumour suppressor genes (deletions, mutations, rearrangements, and amplifications) and epigenetic changes (aberrant hypermethylation) that involve tumour suppressor genes are integral to the pathogenesis. Antigenic stimulation also plays an evident role in the pathogenesis of PTLDs. Plasmacytoid dendritic cells (PDCs) that are critical to fight viral infections have been thought to play a pathogenetically relevant role in P...Continue Reading

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Citations

Aug 29, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·T M WiggillP Willem
May 22, 2013·Clinical & Developmental Immunology·J MorscioT Tousseyn
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Jun 22, 2021·Clinical Lymphoma, Myeloma & Leukemia·Laura McDonaldLiam Smyth
Aug 17, 2021·Case Reports in Gastrointestinal Medicine·Steven ParkArthur Decross

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Methods Mentioned

BETA
chromosomal aberrations

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