Posttransplantation lymphoproliferative disease involving the pituitary gland

Human Pathology
Zina MeridenHelen P Cathro

Abstract

Posttransplantation lymphoproliferative disorders (PTLD) are heterogeneous lesions with variable morphology, immunophenotype, and molecular characteristics. Multiple distinct primary lesions can occur in PTLD, rarely with both B-cell and T-cell characteristics. Lesions can involve both grafted organs and other sites; however, PTLD involving the pituitary gland has not been previously reported. We describe a patient who developed Epstein-Barr virus-negative PTLD 13 years posttransplantation involving the terminal ileum and pituitary, which was simultaneously involved by a pituitary adenoma. Immunohistochemistry of the pituitary lesion showed expression of CD79a, CD3, and CD7 with clonal rearrangements of both T-cell receptor gamma chain (TRG@) and immunoglobulin heavy chain (IGH@) genes. The terminal ileal lesion was immunophenotypically and molecularly distinct. This is the first report of pituitary PTLD and illustrates the potentially complex nature of PTLD.

References

Oct 12, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·S ParanjothiE P Trulock
Jun 28, 2005·Critical Reviews in Oncology/hematology·Anna L TaylorJ Andrew Bradley
Feb 13, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Nicolaas A BakkerWillem J van Son
Oct 23, 2008·The American Journal of Surgical Pathology·Anamarija MorovicJeffrey A Schrager

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Citations

Dec 17, 2015·Molecular Neurobiology·Sheng ChenJianmin Zhang
Oct 10, 2014·Transplant Infectious Disease : an Official Journal of the Transplantation Society·H P CathroN Aguilera
Jan 18, 2014·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Aghil Gholipour-ShoiiliSaeed Taheri

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