Posttraumatic gas-containing brain abscess caused by Clostridium perfringens with unique simultaneous fungal suppuration by Myceliophthora thermophila: case report

Neurosurgery
I H TekkökE C Ventureyra

Abstract

Gas-containing brain abscesses are rare, and the vast majority are caused by Clostridium perfringens. Significant simultaneous fungal infection in a bacterial abscess is even rarer. We present such a case and review the literature. A 21-month-old male patient sustained a penetrating head injury in a barnyard, developed a gas-containing left parietal brain abscess, and presented with high fever, galeal swelling, and seizure. The patient initially underwent debridement of his wound and then repeated aspirations. The initial cultures revealed pure growth of Clostridium perfringens. Despite appropriate antibiotic therapy, serial neuroimaging did not demonstrate a decrease in the size of the cavity. An excision had to be undertaken 6 weeks after the injury. The culture from the excised specimen revealed an unexpected growth of a saprophytic and opportunistic fungus, Myceliophthora thermophila. Antifungal treatment consisting of the administration of liposomal amphotericin B and itraconazole was then performed. The child was well and neurologically intact 6 months after the excision. Our review revealed 38 cases of clostridial brain abscess in the literature. Despite the reputation of the organism, the outcome with clostridial brain ...Continue Reading

References

Jun 1, 1975·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·B Azar-KiaM Schechter
Oct 1, 1992·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·I H Tekkök, A Erbengi
Sep 1, 1990·Journal of Clinical Microbiology·J F LewD McCullough
Nov 1, 1988·The Journal of Infection·D W MackenzieJ H Millar
Oct 1, 1987·The Pediatric Infectious Disease Journal·F E Berkowitz, D W Jacobs
Apr 1, 1966·Journal of Neurosurgery·A Morello, N Bettinazzi
Aug 1, 1968·Journal of Neurology, Neurosurgery, and Psychiatry·P R Clarke
Jan 1, 1973·Postgraduate Medical Journal·A J Keogh
Jun 1, 1970·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·H Norrell, J Howieson
Jul 1, 1984·Annals of Neurology·R F Young, J Frazee
Jan 1, 1984·Neurologia Medico-chirurgica·G Odake
May 1, 1982·Neurology·M F BealR I Grossman
Dec 1, 1981·Surgical Neurology·Y TaguchiN Nakamura
Sep 1, 1995·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J FortúnJ Martínez-San Millán
Jan 1, 1994·British Journal of Neurosurgery·Z Domingo
Mar 1, 1961·American Journal of Surgery·A I GILBERTJ J FARRELL
Nov 1, 1963·The American Journal of Medicine·H S HEINEMAN, A I BRAUDE

❮ Previous
Next ❯

Citations

Dec 31, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sanjay G RevankarMichael G Rinaldi
Feb 12, 2004·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·R Shane Tubbs, W Jerry Oakes
Oct 12, 2010·Clinical Microbiology Reviews·Sanjay G Revankar, Deanna A Sutton
Dec 6, 2014·The Kaohsiung Journal of Medical Sciences·Tsung-Ming SuShih-Wei Hsu
Nov 4, 2016·World Journal of Pediatrics : WJP·Shuang ChenYu-Ping Ran
Mar 27, 1999·The Pediatric Infectious Disease Journal·J G Caya, A L Truant
Sep 12, 2006·Annals of Clinical Microbiology and Antimicrobials·Lauren DestinoMichael J Chusid
Jun 17, 2008·Internal Medicine·Yujiro UchidaMine Harada
Dec 29, 2007·Neurosurgery·Chaim B ColenMurali Guthikonda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Abscess

Brain abscess is an accumulation of pus caused by inflammation and infected materials in the brain. Symptoms include fever, headache, seizures and other neurological problems. Discover the latest research on brain abscess today.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.